Evidence map›Paper›PMID 41970829›Full record

ArticleACS omega2026

Chitosan-Stabilized Silver-Nimesulide Coordination Complex with Enhanced Anti-Inflammatory and Redox-Modulating Activity.

Luis Eduardo M Narvaez, Kely C N Lima, Roseane G Ferreira, Silvia Letícia de F Gaspar, Victor Ricardo C Sousa, Rayane Caroline Dos S Pereira, Jaqueline D N Martins, Lucas da S Gato, Sávio M Dos Santos, Lisa Maria M de A Souza and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Luis Eduardo M NarvaezHealth Science Institute, Federal University of Pará, Belém 66075900, Brazil.ORCID https://orcid.org/0000-0001-7325-6849
Kely C N LimaLaboratory Immunology, Microbiology and In vitro Assays (LABEIM), Faculty of Pharmacy, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil.ORCID https://orcid.org/0000-0001-8613-3223
Roseane G FerreiraLaboratory Immunology, Microbiology and In vitro Assays (LABEIM), Faculty of Pharmacy, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil.ORCID https://orcid.org/0000-0002-6154-8200
Silvia Letícia de F GasparLaboratory Immunology, Microbiology and In vitro Assays (LABEIM), Faculty of Pharmacy, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil.ORCID https://orcid.org/0000-0002-4475-2699
Victor Ricardo C SousaLaboratory Immunology, Microbiology and In vitro Assays (LABEIM), Faculty of Pharmacy, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil.ORCID https://orcid.org/0009-0005-8866-7866
Rayane Caroline Dos S PereiraLaboratory Immunology, Microbiology and In vitro Assays (LABEIM), Faculty of Pharmacy, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil.ORCID https://orcid.org/0009-0005-4883-6186
Jaqueline D N MartinsNeuroscience and Cellular Biology Post Graduation Program, Institute of Biological Sciences, Federal University of Pará, Belém 66075110, Brazil.ORCID https://orcid.org/0000-0002-3377-9482
Lucas da S GatoLaboratory Immunology, Microbiology and In vitro Assays (LABEIM), Faculty of Pharmacy, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil.ORCID https://orcid.org/0009-0005-5113-4177
Sávio M Dos SantosLaboratory Immunology, Microbiology and In vitro Assays (LABEIM), Faculty of Pharmacy, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil.ORCID https://orcid.org/0000-0002-0927-9680
Lisa Maria M de A SouzaLaboratory Immunology, Microbiology and In vitro Assays (LABEIM), Faculty of Pharmacy, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil.ORCID https://orcid.org/0009-0008-7667-7719
Carla Carolina F MenesesLaboratory of Drug Planning and Development, Institute of Exact and Natural Sciences, Federal University of Pará, Belem 66075110, Pará, Brazil.ORCID https://orcid.org/0000-0003-0184-2149
Paulo Robson M de SousaLaboratory of Drug Planning and Development, Institute of Exact and Natural Sciences, Federal University of Pará, Belem 66075110, Pará, Brazil.ORCID https://orcid.org/0000-0002-5232-2285
Cláudio N AlvesLaboratory of Drug Planning and Development, Institute of Exact and Natural Sciences, Federal University of Pará, Belem 66075110, Pará, Brazil.
Marta C MonteiroLaboratory Immunology, Microbiology and In vitro Assays (LABEIM), Faculty of Pharmacy, Health Science Institute, Federal University of Pará, Belém 66075-110, Brazil.ORCID https://orcid.org/0000-0002-3328-5650

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Inflammation and oxidative stress are central mediators of acute and chronic diseases. Here, we present a chitosan-stabilized silver-nimesulide coordination complex engineered to enhance anti-inflammatory and redox-modulating performance while enabling controlled drug release. Spectroscopic and crystallographic analyses confirmed the formation of an Ag-NMS coordination core embedded within a polymeric chitosan matrix. The biocomposite significantly reduced carrageenan-induced edema, MPO activity, and lipid peroxidation, while modulating thiol-dependent redox responses. These findings demonstrate that coordination-driven polymeric stabilization improves the therapeutic profile of nimesulide and supports further preclinical investigation of this multifunctional biocomposite.

Identifiers

PMID41970829
PMCPMC13063181

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.