Evidence map›Paper›PMID 41970813›Full record

ArticleACS omega2026

Effects of Sulfate Metabolites of Chrysin, Quercetin, Luteolin, and Myricetin on the Albumin Binding of Warfarin (Site I) and Biliverdin (Heme Site): from Theoretical to Practical Considerations.

Miklós Poór, Lorenzo Pedroni, Dávid Csabai, Dávid Hesszenberger, Anikó Lajtai, Patrik Gömbös, Tamás Huber, Szilvia Barkó, András Lukács, Paul A Kroon and 3 more

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Article in ACS omega, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Miklós PoórDepartment of Laboratory Medicine, Medical School, University of Pécs, Ifjúság útja 13, Pécs H-7624, Hungary.ORCID https://orcid.org/0000-0003-1425-7459
Lorenzo PedroniDepartment of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, Parma 43124, Italy.
Dávid CsabaiDepartment of Laboratory Medicine, Medical School, University of Pécs, Ifjúság útja 13, Pécs H-7624, Hungary.
Dávid HesszenbergerDepartment of Laboratory Medicine, Medical School, University of Pécs, Ifjúság útja 13, Pécs H-7624, Hungary.
Anikó LajtaiDepartment of Laboratory Medicine, Medical School, University of Pécs, Ifjúság útja 13, Pécs H-7624, Hungary.
Patrik GömbösAgribiotechnology and Precision Breeding for Food Security National Laboratory, Institute of Physiology and Nutrition, Department of Physiology and Animal Health, Hungarian University of Agriculture and Life Sciences, Guba Sándor u. 40, Kaposvár H-7400, Hungary.
Tamás HuberDepartment of Biophysics, Medical School, University of Pécs, Szigeti út 12, Pécs H-7624, Hungary.
Szilvia BarkóDepartment of Biophysics, Medical School, University of Pécs, Szigeti út 12, Pécs H-7624, Hungary.
András LukácsDepartment of Biophysics, Medical School, University of Pécs, Szigeti út 12, Pécs H-7624, Hungary.ORCID https://orcid.org/0000-0001-8841-9823
Paul A KroonFood, Microbiome & Health Programme, Quadram Institute Bioscience, Norwich Research Park, Norwich, Norfolk NR4 7UQ, U.K.ORCID https://orcid.org/0000-0002-9805-6947
Kateřina ValentováInstitute of Microbiology of the Czech Academy of Sciences, Vídeňská 1083, Prague CZ-142 00, Czech Republic.ORCID https://orcid.org/0000-0002-7714-5350
Luca DellafioraDepartment of Food and Drug, University of Parma, Parco Area delle Scienze 27/A, Parma 43124, Italy.ORCID https://orcid.org/0000-0002-1901-3317
Péter HorváthDepartment of Pharmaceutical Chemistry, Semmelweis University, Hőgyes Endre u. 9, Budapest H-1092, Hungary.ORCID https://orcid.org/0000-0001-7149-4173

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Serum albumin carries several ligands in the circulation. Previous studies demonstrated that certain flavonoid aglycones and their sulfate metabolites can influence the albumin binding of Site I ligand drugs. To get a deeper insight, the effects of chrysin, quercetin, luteolin, myricetin, and their sulfate derivatives on the albumin binding of warfarin (Site I) and biliverdin (heme site) were examined. Ultracentrifugation experiments were carried out using human serum albumin (HSA), bovine serum albumin (BSA), human serum, and fetal bovine serum (FBS). In addition, fluorescence spectroscopic and modeling studies (warfarin-HSA) as well as circular dichroism-based measurements (biliverdin-HSA) were also performed. Chrysin-7-

Identifiers

PMID41970813
PMCPMC13063089

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.