Evidence map›Paper›PMID 41970640›Full record

ReviewFrontiers in pain research (Lausanne, Switzerland)2026

Dexmedetomidine vs. midazolam-fentanyl for intraoperative analgesia and sedation: a systematic review and meta analysis.

Hashim Talib Hashim, Mostafa A Khalifa, Aya Ahmed Shimal, Marafi Jammaa Ahmed, Mohamed H Elbadawi, Khadeeja Ali Hamzah, Abdulhadi M A Mahgoub, Alaa R Al-Ihribat, Salem Waleed Salem Mohamed, Fathima Raahima Riyas Mohamed and 5 more

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PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in pain research (Lausanne, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Hashim Talib HashimCollege of Medicine, University of Warith Al-Anbiyaa, Karbala, Iraq.
Mostafa A KhalifaFaculty of Medicine, Cairo University, Cairo, Egypt.
Aya Ahmed ShimalCollege of Medicine, University of Baghdad, Baghdad, Iraq.
Marafi Jammaa AhmedFaculty of Medicine, Bahri University, Khartoum, Sudan.
Mohamed H ElbadawiFaculty of Medicine, University of Khartoum, Khartoum, Sudan.
Khadeeja Ali HamzahBaghdad University AIkindy College of Medicine, Baghdad, Iraq.
Abdulhadi M A MahgoubFaculty of Medicine, University of Gezira, Madani, Gezira, Sudan.
Alaa R Al-IhribatCollege of Medicine and Health Sciences, Polytechnic University, Hebron, Palestine.
Salem Waleed Salem MohamedFaculty of Medicine, Alexandria University, Alexandria, Egypt.
Fathima Raahima Riyas MohamedCollege of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Elian KhalafallaFaculty of Medicine, University of Khartoum, Khartoum, Sudan.
Amna KamilJinnah Sindh Medical University, Karachi, Pakistan.
Anzah Imtiaz WaggaJinnah Sindh Medical University, Karachi, Pakistan.
Ahmed Mohamed ShahinFaculty of Medicine, Menoufia University, Menoufia, Egypt.
Abdelrhman H MohammedCollege of Medicine, Luxor University, Luxor, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Ongoing research aims to identify the most effective sedative for procedural sedation. This meta-analysis compares dexmedetomidine with midazolam-fentanyl in surgical patients. Methods: We conducted a search through MEDLINE, EMBASE and CENTERAL to find randomized controlled trials (RCTs) comparing dexmedetomidine and midazolam-fentanyl. Data on participant characteristics, intervention details, and outcomes were extracted, focusing on intraoperative hemodynamic parameters, respiratory safety, and adverse events. Sedative efficacy and recovery profiles were also evaluated and assessed descriptively across included studies. Data were analyzed using RevMan 5.4, applying random effects models for significant heterogeneity (I Results: We include 4 RCTs with 259 patients. Dexmedetomidine significantly lowered mean arterial pressure (MAP) by -6.42 mmHg (95% CI: -8.24 to -2.21, Conclusion: Dexmedetomidine offers superior blood pressure control compared to midazolam-fentanyl, with similar safety profiles for respiratory parameters. Further research is needed to assess long-term outcomes such as postoperative delirium and residual sedation.

Indexed as

analgesiadexmedetomidinemidazolammidazolam-fentanylsedation

Identifiers

PMID41970640
PMCPMC13066290

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.