ArticleBiomedical optics express2026
Functional OCT with parfocal retinal stimulation enables multi-site optoretinography under a single dark adaptation.
Article in Biomedical optics express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Spatially resolved in vivo ratiometric imaging of mitochondrial quality control using co-registered confocal-OCT.Biomedical optics express · 2026Article
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Authors and funding
6 authors.
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Abstract
Functional optical coherence tomography (OCT) enables depth-resolved imaging of stimulus-evoked intrinsic optical signal (IOS) changes in the retina, providing a noninvasive method for objective optoretinography (ORG) of retinal physiology. However, IOS imaging with raster-scan OCT is limited by long acquisition times, as each recording site typically requires a separate dark-adaptation cycle. To overcome this constraint, we developed a functional OCT system with parfocal retinal stimulation, in which the visible-light stimulus and near-infrared OCT imaging beams are co-registered at the retina. This configuration confines stimulation to a local retinal region with high spatial precision, preserves dark adaptation elsewhere, and enables multi-site IOS acquisition within a single adaptation cycle. Using visible-light flashes with variable bleaching levels (1-100%), we observed robust, spatially localized IOS confined to the stimulated regions of the retina. The IOS amplitude scaled linearly with bleaching level up to approximately 20% and exhibited saturation at higher intensities, consistent with the biophysical limits of phototransduction. This parfocal stimulation strategy establishes a scalable framework for spatially and depth-resolved functional retinal mapping, providing an objective optical analogue to microperimetry and a foundation for site-specific assessment of photoreceptor physiology.
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Registered trials
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