Evidence map›Paper›PMID 41970582›Full record

ArticleBiomedical optics express2026

Reliability of diffuse optical spectroscopies for evaluation of cerebral hemometabolic stress in children with sickle cell anemia.

Giovani G Martins, Rowan O Brothers, Kristin Wubbena, Mariam Akbar, Michael Arrington, Katherine B Turrentine, Sydney Triplett, Hongting Zhao, Tara M Urner, Shasha Bai and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomedical optics express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Giovani G MartinsWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr. NE, Atlanta, GA 30322, USA.ORCID https://orcid.org/0000-0001-6163-489X
Rowan O BrothersWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr. NE, Atlanta, GA 30322, USA.ORCID https://orcid.org/0000-0003-0587-4578
Kristin WubbenaWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr. NE, Atlanta, GA 30322, USA.
Mariam AkbarWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr. NE, Atlanta, GA 30322, USA.
Michael ArringtonWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr. NE, Atlanta, GA 30322, USA.
Katherine B TurrentineWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr. NE, Atlanta, GA 30322, USA.
Sydney TriplettWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr. NE, Atlanta, GA 30322, USA.
Hongting ZhaoWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr. NE, Atlanta, GA 30322, USA.
Tara M UrnerWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr. NE, Atlanta, GA 30322, USA.ORCID https://orcid.org/0000-0001-7030-9255
Shasha BaiPediatric Biostatistics Core, Emory University School of Medicine, Atlanta, GA 30322, USA.
Amy TangDepartment of Pediatrics, Children's Healthcare of Atlanta and Emory University, 1405 Clifton Rd. NE, Atlanta, GA 30322, USA.
Kirshma KhemaniDepartment of Pediatrics, Children's Healthcare of Atlanta and Emory University, 1405 Clifton Rd. NE, Atlanta, GA 30322, USA.
Beatrice E GeeDepartment of Pediatrics, Children's Healthcare of Atlanta and Emory University, 1405 Clifton Rd. NE, Atlanta, GA 30322, USA.
R Clark BrownIllexcor Therapeutics, LLC, 800 E Leigh St, Richmond, VA 23219, USA.
Erin M BuckleyWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, 1760 Haygood Dr. NE, Atlanta, GA 30322, USA.ORCID https://orcid.org/0000-0003-1068-8411

Funding

Diffuse optical spectroscopies to assess cerebral hemodynamics in pediatric sickle cell diseaseR01HL152322 · NHLBI · EMORY UNIVERSITY · PI BUCKLEY, ERIN MCGUIRE, GEE, BEATRICE E · 2021 to 2024
$2.0M
NHLBI NIH HHS R01 HL152322
6 · The paper itself

Abstract

Diffuse optical spectroscopies are promising non-invasive optical techniques that may provide a point-of-care tool to evaluate cerebral hemometabolic stress. This study quantifies the intra- and inter-operator reliability of a battery of cerebral hemometabolic parameters quantified with diffuse correlation spectroscopy (DCS) and frequency-domain near-infrared spectroscopy (FDNIRS) in children with sickle cell anemia. For measures of cerebral blood flow, oxygen extraction fraction, metabolic rate of oxygen, and cerebral blood volume, we found inter-operator concordance correlation coefficients (CCC) ranging from 0.45 to 0.97, intra-operator CCCs ranging from 0.81 to 0.98, and a median coefficient of variation < 16%.

Identifiers

PMID41970582
PMCPMC13064625

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.