ArticleBiomedical optics express2026
Fluorescence lifetime imaging of 5-ALA-induced PpIX and autofluorescence for detecting infiltrating glioblastoma margins in patients.
Article in Biomedical optics express, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
5-aminolevulinic acid (5-ALA) is routinely used in neurosurgery to enhance visualization of glioblastoma multiforme (GBM) and enable more extensive tumor resection. However, intraoperative guidance based solely on 5-ALA-induced protoporphyrin IX (PpIX) fluorescence remains limited by qualitative interpretation, low sensitivity, and insufficient specificity for detecting tumor infiltration at surgical margins - regions critical for minimizing recurrence. Recent studies suggest that brain tissue autofluorescence (AF), which reflects biochemical composition and metabolic state, may provide complementary diagnostic information to PpIX and that could improve margin detection. This study investigates whether fluorescence lifetime (FLT) measurements of PpIX, supplemented by FLT of brain tissue autofluorescence, improve detection of tumor infiltration at the resection margin in patients
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