Evidence map›Paper›PMID 41970540›Full record

ArticleAnnals of surgical treatment and research2026

Effect of weight reduction on liver volume in living liver donors with steatosis: a retrospective cohort study.

Kwangpyo Hong, Kwang-Woong Lee, Su Young Hong, Sola Lee, Hyun Hwa Choi, Jiyoung Kim, Jaewon Lee, Jae-Yoon Kim, Jeong-Moo Lee, Suk Kyun Hong and 1 more

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Article in Annals of surgical treatment and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Kwangpyo HongDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-3220-8506
Kwang-Woong LeeDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-6412-1926
Su Young HongDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-9934-0456
Sola LeeDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-6791-5668
Hyun Hwa ChoiDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-1476-5410
Jiyoung KimDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-7464-8836
Jaewon LeeDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-0248-5553
Jae-Yoon KimDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-2546-3752
Jeong-Moo LeeDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0001-7806-8759
Suk Kyun HongDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0002-0020-6215
YoungRok ChoiDepartment of Surgery, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.ORCID https://orcid.org/0000-0003-2408-7086

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: Weight reduction (WR) can reduce liver volume, affecting the graft-to-recipient weight ratio (GRWR). This study aimed to evaluate the decrease in liver volume after WR and analyze risk factors affecting liver volume reduction in potential liver donors with steatosis. Methods: We retrospectively reviewed data of 147 potential liver donors with steatosis who participated in a WR program prior to liver transplantation between January 2016 and December 2021. Total liver volume (TLV) was measured using CT and MRI. Risk factors for large liver volume reduction (≥10%) were analyzed using multivariate logistic regression. Results: Ninety-seven donors (66.0%) underwent donor hepatectomy after WR. Liver volumes showed a statistically significant decrease (from 1,399.6 ± 315.4 mL to 1,283.6 ± 271.2 mL, P < 0.05). Thirty-eight donors (42.7%) showed large liver volume reduction. There was a more significant reduction in weight, AST, and ALT in the large liver volume reduction group than in the small liver volume reduction group (all P < 0.05). WR percentage and ALT abnormalities were independent risk factors for large liver volume reduction (odds ratio, 1.184 [95% confidence interval, 1.054-1.329] and odds ratio, 5.502 [95% confidence interval, 1.660-18.229], respectively; all P < 0.05). Conclusion: Potential liver donors with 7% or more WR or ALT abnormality require liver volume/GRWR remeasurement after WR to ensure adequate graft size and prevent small-for-size syndrome.

Indexed as

Fatty liverLiver transplantationLiving donorNon-alcoholic fatty liver diseaseWeight loss

Identifiers

PMID41970540
PMCPMC13062662

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