ArticleCirculation reports2026
Impact of the Coronavirus Disease 2019 (COVID-19) Pandemic on Infective Endocarditis Outcomes in Japan: A Nationwide Observational Study.
Article in Circulation reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Infective endocarditis (IE) is a life-threatening condition with high mortality. The Coronavirus disease 2019 (COVID-19) pandemic disrupted healthcare systems, potentially affecting IE management and outcomes. However, its impact in Japan remains unclear. This study aimed to evaluate the impact of the COVID-19 pandemic on in-hospital mortality and the rate of valve surgery among patients with IE in Japan. Methods and Results: We conducted a retrospective analysis using the Japanese registry of all Cardiac and Vascular Diseases Diagnostic Procedure Combination (JROAD-DPC) nationwide database, including 19,077 adult patients hospitalized with IE between April 2016 and March 2022. The study period was divided into pre-COVID-19 (n=12,419) and post-COVID-19 (n=6,658) periods. Patient baseline characteristics were well-balanced after 1 : 1 propensity score matching (6,652 pairs). Before matching, crude total in-hospital mortality was higher in the post-COVID-19 period (15.7% vs. 13.9%; P<0.001). However, after matching, there were no significant differences in total in-hospital mortality (15.7% vs. 15.3%, P=0.60). The rate of valve surgery did not differ significantly between the groups after matching (26.4% vs. 25.5%; P=0.22). The incidence of stroke was higher in the post-COVID-19 period (8.3% vs. 7.3%; P=0.049). Conclusions: This nationwide study showed that risk-adjusted in-hospital mortality in patients with IE was not different during the COVID-19 pandemic, although unadjusted mortality was higher in the post-COVID-19 period in Japan.
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