ArticleHealth science reports2026
Preventing Mother to Child Transmission of Human Immunodeficiency Virus: 20-Year Trends in Management and Clinical Practice in a French Hospital - A Retrospective Observational Study.
Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and Aims: Since the discovery of human immunodeficiency virus (HIV) mother to child transmission (MTCT), its prevention has been a priority. Guideline adherence has drastically reduced MTCT, virtually inexistent today in high-income countries. Methods: Our retrospective study included consecutive pregnant women with HIV who delivered in the Montpellier University Hospital between 2000 and 2020. We sought to examine our center's practices, outcomes, and illustrate the changes in management of pregnant women infected with HIV. Based on significant changes in French HIV guidelines and ART recommendations, we defined timelines for mode of conception, ART strategy, mode of delivery, and pediatric guidelines. These periods were compared to assess changes in our practice. Results: We included 144 women and report a total of 194 pregnancies-of which 39 repeat pregnancies and 9 twin pregnancies-resulting in 201 live births. Between 2000 and 2020, 27 (13.9%) women discovered their HIV-positive status during pregnancy. Over these 20 years, maternal antiretroviral therapy (ART) was started progressively earlier during pregnancy ( Conclusion: Our study illustrates the major changes for the prevention of HIV MTCT. Our findings highlight how early and effective triple ART led to better obstetrical outcomes requiring fewer medical interventions. Thorough treatment, aligned with national guidelines, can virtually eliminate MTCT, serving as a model for global practice.
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