Objectives: We report a case of Methods: A 34-year-old male patient developed high fever and fatigue after exposure to poultry. He presented to the hospital for treatment. Chest computed tomography (CT) showed a high-density shadow in the deep area of the left lower lung. Sputum culture returned negative. Empirical treatment with multiple antibiotics was given. No improvement was observed in the patient's condition. Next-generation sequencing (NGS) was performed on bronchoalveolar lavage fluid. It confirmed the diagnosis of Results: This case report indicates that in patients with high fever, clinicians should first determine the etiological factors and identify the lesion site. Accurate diagnosis can thus be achieved. In this case, the lesion was deeply located in the lung. Even with sensitive antibiotics, complete elimination of the lesion was difficult. Therefore, active pulmonary rehabilitation intervention should be implemented promptly. It promotes airway clearance, sputum excretion, and secretion drainage. It also accelerates the patient's recovery process.