Evidence map›Paper›PMID 41970279›Full record

ArticleNAR cancer2026

MYC and AP-1 oncogenes cooperatively bind enhancers to rewire transcription.

Reshma Kalyan Sundaram, Kshitiz Parihar, Stephanie Monson, Ravi Radhakrishnan, Bomyi Lim

Abstract read
In one paragraph

Article in NAR cancer, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Reshma Kalyan SundaramDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, 19104, United States.ORCID 0000-0001-7041-651X
Kshitiz PariharDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, 19104, United States.ORCID 0000-0002-1072-1798
Stephanie MonsonDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, 19104, United States.ORCID 0009-0007-8287-2505
Ravi RadhakrishnanDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, 19104, United States.ORCID 0000-0003-0686-2851
Bomyi LimDepartment of Chemical and Biomolecular Engineering, University of Pennsylvania, Philadelphia, PA, 19104, United States.ORCID 0000-0002-3058-9181

Funding

A physical sciences approach to investigate the role of exosomes in metastatic progressionU01CA250044 · NCI · UNIVERSITY OF PENNSYLVANIA · PI GUO, WEI, RADHAKRISHNAN, RAVI · 2021 to 2025
$3.9M
NCI NIH HHS U01 CA250044NIH HHS EB01775309
6 · The paper itself

Abstract

The transcription factor c-MYC (MYC) is deregulated in ~70% of human cancers. Through

Indexed as

Enhancer Elements, GeneticNeoplasmsProto-Oncogene Proteins c-mycTranscription Factor AP-1Transcription, GeneticBinding SitesCell Line, TumorGene Expression Regulation, NeoplasticHumansOncogenesPromoter Regions, GeneticProtein BindingMYC protein, humanProto-Oncogene Proteins c-mycTranscription Factor AP-1

Identifiers

PMID41970279
PMCPMC13069683

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.