Evidence map›Paper›PMID 41970256›Full record

ArticleMaterials today. Bio2026

Precise and rapid release of X-ray activated autophagy inhibitors for radiotherapy sensitization of hypopharyngeal carcinoma.

Xinyuan Luo, Rui Rong, Jiao Zhou, Qiongling Huang, Yanjun Huang, Xiaofang Chen, Ming Lu, Shenjiong Ruan, Kehui Chen, Yuanchang Zhou and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xinyuan LuoDepartment of Otolaryngology, the Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, 362000, China.
Rui RongState Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, China.
Jiao ZhouDepartment of Otolaryngology, the Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, 362000, China.
Qiongling HuangDepartment of Otolaryngology, the Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, 362000, China.
Yanjun HuangDepartment of Otolaryngology, the Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, 362000, China.
Xiaofang ChenDepartment of Otolaryngology, the Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, 362000, China.
Ming LuDepartment of Otolaryngology, the Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, 362000, China.
Shenjiong RuanDepartment of Otolaryngology, the Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, 362000, China.
Kehui ChenDepartment of Otolaryngology, the Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, 362000, China.
Yuanchang ZhouDepartment of Otolaryngology, the Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, 362000, China.
Zexin LiDepartment of Otolaryngology, the Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, 362000, China.
Jiwang ZhangDepartment of Otolaryngology, the Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, 362000, China.
Yun ZhangState Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian, 350002, China.
Chaohui ZhengDepartment of Otolaryngology, the Second Affiliated Hospital, Fujian Medical University, Quanzhou, Fujian, 362000, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protective autophagy represents a major factor responsible for radiotherapy resistance in tumor cells, leading to therapeutic failure, metastasis, and recurrence. Autophagy inhibitors can enhance radiosensitivity by suppressing protective autophagy in tumor. However, the usage of autophagy inhibitors is limited by the issues including non-specific release and delayed delivery. In this work, we develop an X-ray-activatable nanocarrier ZGGC@MON-CQ (ZMC) for precise and rapid release of autophagy inhibitors in tumor cells which enables significantly enhanced radiosensitization. The designed ZMC can precisely probe tumors via background-free fluorescence under the guidance of afterglow of high signal-to-noise ratio 50.7 which specifically enhanced by the tumor microenvironment (TME). Under X-ray irradiation, the tetrasulfide-incorporated mesoporous silica coating on the surface of afterglow nanoparticle undergoes cleavage, leading to rapid release of the autophagy inhibitors (50% released within 20 min). The efficient release is facilitated by a highly active redox-cleavage reaction between the tetrasulfide bonds and the abundant H

Indexed as

Autophagy inhibitorPrecise releaseRadiosensitizationRadiotherapy resistanceRapid release

Identifiers

PMID41970256
PMCPMC13068793

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.