Evidence map›Paper›PMID 41970166›Full record

ArticleEvolutionary applications2026

Selection for Function in Early Life: Implications for Early-Onset Pathologies.

Klara Asselin, Antoine M Dujon, Jean-Pascal Capp, Jean-François Lemaître, Florence Pirard, Daniel Vaiman, Beata Ujvari, Pascal Pujol, James DeGregori, Aurora M Nedelcu and 1 more

Abstract read
In one paragraph

Article in Evolutionary applications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Klara AsselinCREEC/CANECEV, MIVEGEC (CREES) Department, University of Montpellier, CNRS, IRD Montpellier France.ORCID https://orcid.org/0009-0000-0430-646X
Antoine M DujonCREEC/CANECEV, MIVEGEC (CREES) Department, University of Montpellier, CNRS, IRD Montpellier France.ORCID https://orcid.org/0000-0002-1579-9156
Jean-Pascal CappToulouse Biotechnology Institute University of Toulouse, INSA, CNRS, INRAE Toulouse France.ORCID https://orcid.org/0000-0002-6470-079X
Jean-François LemaîtreUniversité Lyon 1 CNRS, UMR5558, Laboratoire de Biométrie et Biologie Évolutive Villeurbanne France.ORCID https://orcid.org/0000-0001-9898-2353
Florence PirardSchool of Life and Environmental Sciences Deakin University Waurn Ponds Victoria Australia.ORCID https://orcid.org/0009-0007-8307-3430
Daniel VaimanInstitut Cochin U1016, INSERM, UMR8104 CNRS, Université de Paris Paris France.ORCID https://orcid.org/0000-0002-1915-0717
Beata UjvariSchool of Life and Environmental Sciences Deakin University Waurn Ponds Victoria Australia.ORCID https://orcid.org/0000-0003-2391-2988
Pascal PujolCREEC/CANECEV, MIVEGEC (CREES) Department, University of Montpellier, CNRS, IRD Montpellier France.ORCID https://orcid.org/0000-0001-8315-4715
James DeGregoriDepartment of Biochemistry and Molecular Genetics University of Colorado Anschutz Medical Campus Aurora Colorado USA.ORCID https://orcid.org/0000-0002-1287-1976
Aurora M NedelcuDepartment of Biology University of New Brunswick Fredericton New Brunswick Canada.ORCID https://orcid.org/0000-0002-7517-2419
Frédéric ThomasCREEC/CANECEV, MIVEGEC (CREES) Department, University of Montpellier, CNRS, IRD Montpellier France.ORCID https://orcid.org/0000-0003-2238-1978

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Persistent pathological structures, such as tumors, fibrotic nodules, granulomas, microbial biofilms, or protein aggregates, are traditionally viewed as age-related conditions that emerge after reproduction, when natural selection is less effective at eliminating traits expressed late in life. However, some pathologies with robust and organized architectures can arise surprisingly early, challenging this classical perspective. We recently proposed that intra-organismal

Identifiers

PMID41970166
PMCPMC13067062

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.