Evidence map›Paper›PMID 41970145›Full record

ArticleCase reports in anesthesiology2026

2-Chloroprocaine vs. Lidocaine in a Patient With Hypermobile Ehlers-Danlos Syndrome and a History of Local Anesthetic Resistance: A Case Report.

Jayanth Dasika, Zachary B Deutch, Amie L Hoefnagel

Abstract read
In one paragraph

Article in Case reports in anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jayanth DasikaDepartment of Anesthesiology UF Health Jacksonville, University of Florida-Jacksonville, Jacksonville, Florida, USA, ufl.edu.ORCID https://orcid.org/0000-0003-3961-1311
Zachary B DeutchUS Anesthesia Partners, Palm Coast, Florida, USA.ORCID https://orcid.org/0009-0004-1287-6330
Amie L HoefnagelDepartment of Anesthesiology UF Health Jacksonville, University of Florida-Jacksonville, Jacksonville, Florida, USA, ufl.edu.ORCID https://orcid.org/0000-0002-5330-1419

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with hypermobile Ehlers-Danlos syndrome (hEDS) have a higher reported prevalence of local anesthetic (LA) resistance and obstetric complications than the general population. We describe a 33-year-old G2P0010 ASA III parturient with a history of hEDS and lidocaine resistance who presented for an anesthesia consultation in anticipation of possible neuraxial anesthesia. We surmised that performing a neuraxial procedure would require effective skin infiltration of the patient's lumbar area. A skin infiltration test revealed that 3% 2-chloroprocaine provided a much greater numbing effect than 2% lidocaine. The patient desired an unmedicated birth and ultimately delivered in this fashion. Still, our findings highlight the potential benefit of testing multiple LAs in hEDS patients to guide anesthetic planning.

Identifiers

PMID41970145
PMCPMC13067300

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.