ArticleCureus2026
BRAF-Mutated and Morphologically Spitzoid Tumor Arising Within a Congenital Melanocytic Nevus in a Pediatric Patient: A Diagnostic Challenge.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
B-Raf proto-oncogene, serine/threonine kinase (BRAF)-mutated and morphologically spitzoid tumors (BAMS) are a recently described subset of melanocytic neoplasms characterized by spitzoid histomorphology in the presence of canonical BRAF mutations, most commonly BRAF V600E (valine-to-glutamic acid substitution at codon 600). These lesions may clinically and histologically mimic Spitz nevus, atypical Spitz tumor, or spitzoid melanoma, creating diagnostic challenges. We report the case of an 11-year-old previously healthy female with a congenital melanocytic nevus who developed a new papular lesion within the nevus. Histopathologic evaluation revealed a spitzoid melanocytic proliferation with atypical features. Immunohistochemistry supported melanocytic differentiation with a low proliferative index, and molecular testing detected a BRAF V600E mutation. An integrated clinicopathologic and molecular assessment established the diagnosis of BAMS. The patient underwent complete surgical excision with planned close follow-up. This case highlights the importance of molecular testing in spitzoid melanocytic lesions and emphasizes the need for accurate classification to guide appropriate management.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.