ArticleCureus2026
Beyond the Aorta: Incidental Atrial Septal Defect in a Patient With Marfan Syndrome and Severe Aortic Dilation.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder caused by mutations in the FBN1 gene, which carries a high risk of cardiovascular morbidity and mortality. We present the case of a 31-year-old man with a severe Marfanoid phenotype who was admitted with decompensated heart failure, septic shock, and renal failure. After stabilization, multimodal evaluation revealed a severely dilated aortic root and severe aortic regurgitation, along with an incidental 11 mm ostium secundum atrial septal defect (ASD). This unusual combination caused critical biventricular overload. The patient underwent a successful Bentall-Bono procedure and closure of the ASD. This case underscores the importance of a thorough physical examination and comprehensive diagnosis for successful surgery in patients with complex connective tissue disorders.
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