Evidence map›Paper›PMID 41969822›Full record

ArticleBrain, behavior, & immunity - health2026

Kynurenine pathway metabolites are increased in inflammatory depression and decrease with omega-3 treatment.

Jesper Lindahl, Gustav Söderberg Veibäck, Klara Suneson, Wilma Blanking, Johanna Tjernberg, Darya Ståhl, Åsa Wiman, Filip Ventorp, Sophie Erhardt, Daniel Lindqvist

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain, behavior, & immunity - health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Jesper LindahlUnit for Biological and Precision Psychiatry, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Gustav Söderberg VeibäckUnit for Biological and Precision Psychiatry, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Klara SunesonUnit for Biological and Precision Psychiatry, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Wilma BlankingUnit for Biological and Precision Psychiatry, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Johanna TjernbergUnit for Biological and Precision Psychiatry, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Darya StåhlUnit for Biological and Precision Psychiatry, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Åsa WimanDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Filip VentorpUnit for Biological and Precision Psychiatry, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.
Sophie ErhardtDepartment of Physiology and Pharmacology, Karolinska Institutet, Stockholm, Sweden.
Daniel LindqvistUnit for Biological and Precision Psychiatry, Department of Clinical Sciences Lund, Lund University, Lund, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Activation of the kynurenine pathway (KP) with resulting accumulation of neuroactive metabolites may be a downstream pathophysiological mechanism of inflammatory depression. The aims of this study were to investigate KP metabolites in inflammatory depression compared to non-inflammatory depression and healthy controls, and whether these metabolites change with nutraceutical interventions with potential KP-modulating effects. We combined data from two antidepressant clinical trials: one with omega-3 polyunsaturated fatty acids (n-3 PUFAs) and one with a

Indexed as

Kynurenine pathwayMajor depressive disorderN-3 PUFAsNutraceuticalsProbioticsTryptophan

Identifiers

PMID41969822
PMCPMC13066792

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.