Evidence map›Paper›PMID 41969821›Full record

ReviewJournal of orthopaedic translation2026

Epigenetic transcriptional regulation of skeletal aging: The emerging role of m

Changheng Song, Guanhui Song, Shan Zhang, Hongyan Zhao, Zhige Wen, Yupeng Chen, Xin Chen, Bin Liu, Qing Ni, Danping Fan

Abstract readReview
In one paragraph

Review in Journal of orthopaedic translation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Changheng SongDepartment of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
Guanhui SongExperimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Shan ZhangDepartment of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
Hongyan ZhaoExperimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Zhige WenDepartment of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
Yupeng ChenDepartment of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
Xin ChenShandong First Medical University & Shandong Academy of Medical Sciences, Jinan, Shandong, 250118, China.
Bin LiuInstitute of Clinical Basic Medicine of Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, China.
Qing NiDepartment of Endocrinology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, 100053, China.
Danping FanExperimental Research Center, China Academy of Chinese Medical Sciences, Beijing, 100700, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bone plays critical roles in providing mechanical support, maintaining mineral homeostasis, and facilitating hematopoiesis. However, its structure and function progressively deteriorate with age. Although peak bone mass is achieved in early adulthood, aging is associated with decreased bone density, increased marrow adiposity, and accelerated bone turnover, collectively elevating the risk of fractures and osteoporosis (OP). With the growing elderly population worldwide, the socioeconomic burden of skeletal disorders-particularly OP-has intensified, highlighting the urgent need to elucidate their underlying molecular mechanisms for improved clinical management. Emerging evidence indicates that RNA modifications, especially N

Indexed as

Bone homeostasism6A methylationOsteoblastOsteoclastOsteocyteSkeletal aging

Identifiers

PMID41969821
PMCPMC13068658

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.