ArticleFrontiers in cellular and infection microbiology2026
Duodenal microbiota profiling and its effects on gastrointestinal tract dysfunction.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Duodenal microbiota has been proposed to be associated with gastrointestinal dysfunction, but population-based data are sparse. Profiling duodenal microbiota using 16S rRNA approach would appear to be a powerful tool for better understanding its role in gastrointestinal manifestations. Methods: In a population-based cross-sectional study, 265 adult subjects chosen randomly underwent symptom assessment, upper endoscopy, and gastroduodenal biopsies, with collection of duodenal brushing specimens. The 16S rRNA gene (V3-V4 region) sequencing was conducted using Illumina Results: The five most abundant genera in individuals with a normal duodenum were Conclusion: Alterations of duodenal microbiota signatures are linked to smoking, aging, BMI, education and gastroduodenal disorders. Further mechanistic studies are warranted to further explore the potential effects of duodenal microbiota on gastrointestinal health.
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