Evidence map›Paper›PMID 41969650›Full record

ArticleFrontiers in cellular and infection microbiology2026

Integrated mechanistic and bioinformatics analysis of a traditional Chinese medicine compound MangHuang solution against

Hansheng Zhu, Peijian Ma, Yefei Yuan, Yiping Chen, Hao Shi, Changyi Huang, Yue Zhou, Renzhi Jing, Mei Cao, Dan Zhang and 1 more

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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Hansheng ZhuSchool of Pharmacy, Southwest Medical University, Luzhou, China.
Peijian MaSchool of Pharmacy, Southwest Medical University, Luzhou, China.
Yefei YuanSchool of Pharmacy, Southwest Medical University, Luzhou, China.
Yiping ChenKey Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu, China.
Hao ShiKey Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu, China.
Changyi HuangKey Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu, China.
Yue ZhouKey Laboratory of Biological Resource and Ecological Environment of Chinese Education Ministry, College of Life Sciences, Sichuan University, Chengdu, China.
Renzhi JingR&D Department, Sichuan Golden Stone Hanfang Biotechnology Co., Ltd, Chengdu, China.
Mei CaoCore Laboratory, School of Medicine, Sichuan Provincial People's Hospital Affiliated to University of Electronic Science and Technology of China, Chengdu, China.
Dan ZhangSchool of Pharmacy, Southwest Medical University, Luzhou, China.
Yu LuoSchool of Pharmacy, Southwest Medical University, Luzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: The growing prevalence of drug-resistant pathogens urgently calls for new treatment strategies. Traditional Chinese medicine (TCM) formulas, with their multi-targeted mechanisms of action, offer promising alternative options for antimicrobial therapy. This study aims to evaluate the antimicrobial activity of the TCM formula MangHuang solution (MH) after content detection of tannin, composed of Methods: MH and its individual or combined components were prepared and evaluated for their inhibitory effects on Results: MH demonstrated potent and rapid antibacterial activity. Biofilm formation was significantly inhibited, manifested by reduced cell surface hydrophobicity, weakened initial adhesion capacity, and impaired biofilm maturation processes. Transcriptome and metabolome analyses revealed significant alterations in key metabolic pathways, particularly ABC transporters, amino acid biosynthesis, and protein-related pathways. Discussion: MH exhibits potent antifungal activity against

Indexed as

Antifungal AgentsCandida albicansComputational BiologyDrugs, Chinese HerbalBiofilmsEscherichia coliGene Expression ProfilingMedicine, Chinese TraditionalMicrobial Sensitivity TestsMicroscopy, Electron, TransmissionMultiomicsStaphylococcus aureusTanninsAntifungal AgentsDrugs, Chinese HerbalTanninsantifungal mechanismCandida albicansMangHuang compound solutionmulti-omics analysisTraditional Chinese medicine

Identifiers

PMID41969650
PMCPMC13066265

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.