Evidence map›Paper›PMID 41969649›Full record

ArticleFrontiers in cellular and infection microbiology2026

Vitamin D deficiency in mice modulates oral microbiome stability over time and leads to changes in host inflammatory gene expression pathways.

Lisa Kathleen Ryan, Ana E Duran-Pinedo, Daniel W Irelan, Braden Mulcahy, Michelle Galeas-Pena, Sarah C Glover, Jorge Frias-Lopez, Gill Diamond

Abstract read
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In one paragraph

Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lisa Kathleen RyanDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, University of Louisville, Louisville, KY, United States.
Ana E Duran-PinedoDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, FL, United States.
Daniel W IrelanDivision of Gastroenterology and Hepatology, Department of Medicine, Tulane University Medical School, New Orleans, LA, United States.
Braden MulcahyDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, University of Louisville, Louisville, KY, United States.
Michelle Galeas-PenaDivision of Gastroenterology and Hepatology, Department of Medicine, Tulane University Medical School, New Orleans, LA, United States.
Sarah C GloverDivision of Gastroenterology and Hepatology, Department of Medicine, Tulane University Medical School, New Orleans, LA, United States.
Jorge Frias-LopezDepartment of Oral Biology, University of Florida College of Dentistry, Gainesville, FL, United States.
Gill DiamondDepartment of Oral Immunology and Infectious Diseases, University of Louisville School of Dentistry, University of Louisville, Louisville, KY, United States.

Funding

Initiation of immune responses to SARS COV2 in the oral cavity and upper airwayR01DE031928 · NIDCR · UNIVERSITY OF MISSISSIPPI MED CTR · PI GILL DIAMOND, SARAH C GLOVER · 2022 to 2026
$3.8M
Topical Vitamin D and Periodontal DiseaseR01DE028883 · NIDCR · UNIVERSITY OF LOUISVILLE · PI GILL DIAMOND, Keith L Kirkwood · 2021 to 2026
$3.2M
NIDCR NIH HHS R01 DE028883NIDCR NIH HHS R01 DE031928
6 · The paper itself

Abstract

Introduction: We previously showed that vitamin D deficiency leads to gingival inflammation and alveolar bone loss in mice, and that topical vitamin D Methods: This was a 13-week study, with a group crossover period at week 7. Oral microbiomes were sampled weekly. At the end of the 13 weeks, single-cell analysis was performed on the gingival and buccal tissues. Results: During the first 6 weeks, the vitamin D Discussion: This showed that elimination of vitamin D

Indexed as

InflammationMicrobiotaMouthVitamin D DeficiencyAlveolar Bone LossAnimalsDietDisease Models, AnimalMaleMiceMice, Inbred C57BLendotheliumenterococcusfusobacteriuminflammatory cellsoral epitheliumperiodontal diseasetranscriptomicsvitamin D deficiency

Identifiers

PMID41969649
PMCPMC13066305

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.