Evidence map›Paper›PMID 41969602›Full record

ReviewOsteoporosis and sarcopenia2026

Asia-Pacific consensus statement on medication-related osteonecrosis of the jaw in patients with osteoporosis.

Akira Taguchi, Daisuke Inoue, Jin-Woo Kim, Keskanya Subbalekha, Wai Sin Chan, Hee Dong Chae, Chung-Hwan Chen, Ching-Lung Cheung, Eddie Siu Lun Chow, Yoon-Sok Chung and 22 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Osteoporosis and sarcopenia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

32 authors.

Akira TaguchiDepartment of Oral and Maxillofacial Radiology, School of Dentistry, Matsumoto Dental University, Nagano, Japan.
Daisuke InoueDivision of Endocrinology and Metabolism, Third Department of Medicine, Teikyo University Chiba Medical Center, Chiba, Japan.
Jin-Woo KimDepartment of Oral & Maxillofacial Surgery, Ewha Womans University Mokdong Hospital, School of Medicine, Ewha Womans University, Seoul, South Korea.
Keskanya SubbalekhaDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Bangkok, Thailand.
Wai Sin ChanDepartment of Internal Medicine Orthopaedics, Centro Hospitalar Conde de Sao Januario, Macao, China.
Hee Dong ChaeDepartment of Obstetrics and Gynecology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea.
Chung-Hwan ChenOrthopaedic Research Center and Department of Orthopedics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan.
Ching-Lung CheungDepartment of Pharmacology and Pharmacy, Li Ka Shing Faculty of Medicine, The University of Hong Kong, China.
Eddie Siu Lun ChowTMH Rehabilitation Centre and Department of Medicine & Geriatrics, Tuen Mun Hospital, China.
Yoon-Sok ChungDepartment of Endocrinology and Metabolism, Ajou University School of Medicine, Suwon, South Korea.
Linsey GaniDepartment of Endocrinology, Changi General Hospital, Singapore, and LG Endocrinology, Novena Medical Centre, Singapore.
Muhammad Kamil Bin HassanDepartment of Oral & Maxillofacial Clinical Services, Universiti Malaya, Kuala Lumpur, Malaysia.
Unnop JaisamrarnCenter of Excellence in Menopause and Aging Women's Health, Department of Obstetrics and Gynecology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Chakorn VorakulpipatDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
Nutchada SriyaranyaDepartment of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chiangmai University, Chiangmai, Thailand.
Aasis UnnanuntanaFaculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Tanawat AmphansapDepartment of Orthopaedic Surgery, Police General Hospital, Bangkok, Thailand.
Seng Bin AngMenopause Unit and Family Medicine Service, KK Women's and Children's Hospital, Singapore, Singapore.
Fen Lee HewDepartment of Medicine, Subang Jaya Medical Centre, Subang Jaya, Selangor, Malaysia.
Julie Li-YuDepartment of Medicine, University of Santo Tomas Hospital and UST Faculty of Medicine and Surgery, Manila, Philippines.
Terence Ong Ing WeiDepartment of Medicine, Faculty of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Jeyakantha RatnasingamEndocrine Unit, Department of Medicine, Universiti Malaya, Kuala Lumpur, Malaysia.
Mark Anthony SandovalDepartments of Physiology and Medicine, College of Medicine and Philippine General Hospital, University of the Philippines Manila, Manila, Philippines.
Thawee SongpatanasilpDepartment Orthopaedic Surgery, Phramongkutklao Hospital and College of Medicine, Bangkok, Thailand.
Monica Therese Cating-CabralSection of Endocrinology, Diabetes, and Metabolism, Department of Medicine, University of the Philippines, Philippine General Hospital, Manila, Philippines.
Thanut ValleenukulDepartment of Orthopaedic Surgery, Bhumibol Adulyadej Hospital, Bangkok, Thailand.
Lalita WattanachanyaDivision of Endocrinology and Metabolism Department of Medicine, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
Chih-Hsing WuDepartment of Family Medicine, National Cheng Kung University Hospital, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Weibo XiaDepartment of Endocrinology, Key Laboratory of Endocrinology, National Commission of Health, State Key Laboratory for Complex, Severe, and Rare Diseases, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China.
Jawl-Shan HwangDivision of Endocrinology and Metabolism, Department of Internal Medicine, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan City, Taiwan.
Hiroshi HaginoSanin Rosai Hospital, Yonago, Tottori, Japan.
Natthinee CharatcharoenwitthayaDivision of Endocrinology and Metabolism Department of Medicine, Faculty of Medicine, Thammasat University, Pathum Thani, Thailand.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A unified consensus statement on medication-related osteonecrosis of the jaw (MRONJ) has not yet been established among the Asian member countries or regions of the Asian Federation of Osteoporosis Societies (AFOS). This study aimed to develop a consensus on MRONJ in patients with osteoporosis across these countries and regions. In this study, the term "Asia-Pacific" refers specifically to the Asian member countries and regions of AFOS. A structured survey consisting of nine MRONJ-related questions was distributed across 10 countries and regions to assess the level of agreement and summarize regional perspectives. In addition, a manual literature review and voting were conducted to evaluate the current evidence on MRONJ. The key aspects of MRONJ, including definition, staging, diagnosis, pathogenesis, risk factors, management, and prevention, were generally consistent among the AFOS countries and regions. The annual incidence and incidence rate of MRONJ associated with low-dose antiresorptive therapy in patients with osteoporosis ranged from 0.025% to 0.136% and 21 to 283 cases per 100,000 person-years, respectively. However, evidence regarding the benefits of drug discontinuation before dental surgery, such as tooth extraction, remains insufficient. Large-scale, multinational studies across AFOS countries and regions are warranted to determine the incidence of MRONJ better and evaluate the impact of antiresorptive drug discontinuation before dental procedures. These findings may contribute to the development of effective evidence-based strategies for preventing MRONJ in patients with osteoporosis.

Indexed as

Anti-resorptive agentsConsensusOsteonecrosis of the jawOsteoporosisPreventive strategy

Identifiers

PMID41969602
PMCPMC13069298

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.