ArticleJournal of research in pharmacy practice2026
Prospective Evaluation of Cephalosporin Prescribing and Guideline Adherence in Adult Inpatients at a Tertiary Care Hospital in South India.
Article in Journal of research in pharmacy practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to assess cephalosporin prescribing patterns, clinical appropriateness, susceptibility and resistance profiles, potential drug-drug interactions, and de-escalation practices in the management of infectious diseases. Methods: This prospective observational study was conducted over 6 months (May-October 2024) at a tertiary care hospital in South India. A total of 288 adult patients (>18 years) who received at least one cephalosporin prescription were included. Relevant demographic, clinical, and prescription data were collected from the patient case records. The appropriateness of antimicrobial therapy was evaluated according to the Indian Council of Medical Research antimicrobial stewardship guidelines. Data were entered into Microsoft Excel and analyzed using IBM SPSS Statistics version 20.0. Findings: Among the 288 patients, 383 cephalosporin prescriptions were documented. Culture testing was performed in 63% ( Conclusion: Third-generation cephalosporins were predominantly prescribed in the study population. Although cephalosporins remain important and accessible therapeutic agents, inappropriate and empirical prescribing practices contribute to the rising antimicrobial resistance. Rational use guided by culture sensitivity results and antimicrobial stewardship principles is essential to preserve their clinical efficacy and limit further resistance.
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