ArticleJournal of research in pharmacy practice2026
Effect of Ultra-low-dose Naloxone on Ileus after Cesarean Section: A Randomized Clinical Trial.
Article in Journal of research in pharmacy practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
7 authors.
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Abstract
Objective: Postoperative ileus commonly occurs after abdominal surgeries, often leading to longer hospital stays. While intravenous opioids are effective for pain management, they can extend ileus duration. Ultra-low-dose naloxone presents a promising strategy to improve pain control and minimize side effects. This study examines how ultra-low-dose naloxone impacts ileus after cesarean section. Methods: Seventy participants were randomly divided into two groups: 35 patients in the intervention group received a patient-controlled analgesia (PCA) pump with 30 mg of morphine, 0.25 μg/kg/h of naloxone, and saline, whereas 35 patients in the control group received morphine and saline only. Patients assessed their pain, nausea, and pruritus using a 0-10-point Visual Analog Scale upon arrival at the recovery room and then at 30 min, 60 min, 90 min, 120 min, 6 h, 12 h, and 24 h after surgery. We recorded the duration of ileus, time to tolerate liquids and solids, discharge timing, and analgesic consumption. Findings: The control group ( Conclusions: Ultra-low-dose naloxone can effectively reduce postoperative ileus, improve opioid analgesia, and decrease side effects such as pruritus and nausea.
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