ArticleOncology letters2026
Efficacy and safety of concurrent chemoradiotherapy following neoadjuvant chemoimmunotherapy in patients with stage III NSCLC who experienced neoadjuvant failure: A real-world study.
Article in Oncology letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neoadjuvant chemoimmunotherapy followed by surgery markedly improves outcomes in patients with stage III unresectable non-small cell lung cancer (NSCLC). However, the efficacy and safety of continuing concurrent chemoradiotherapy (cCRT) followed by immunotherapy consolidation in patients who experience failure of neoadjuvant treatment remain unclear. The present real-world study included patients who received cCRT and consolidation immunotherapy after failure of neoadjuvant chemoimmunotherapy at The Second Affiliated Hospital of Nanchang University, Nanchang, China, between May 2018 and August 2024. The primary endpoint was progression-free survival (PFS), and the secondary endpoints were treatment-related adverse events and overall survival (OS). PFS time among patients who experienced neoadjuvant treatment failure was compared with that of patients with unresectable stage III NSCLC treated with the PACIFIC regimen at the same center. A total of 67 patients were included. The median PFS time was 26.0 months (95% CI, 17.8-39.0), with 1-, 2- and 3-year OS rates of 92.5, 79.1 and 77.6%, respectively. The incidence of immune-related adverse events was 34.33% and radiation-related adverse events occurred in 63.2% of patients. Grade ≥3 immunotherapy-related pneumonitis occurred in 5.97% of cases and radiation-related pneumonitis occurred in 4.48%. Comparison with 30 patients previously treated with the PACIFIC regimen showed no significant difference in PFS (HR, 1.155; 95% CI, 0.657-2.032; P=0.615). Notably, treatment-related adverse events were frequent, with bone marrow suppression observed in 86.57% of cases. In conclusion, induction immunotherapy combined with chemotherapy followed by cCRT and immunotherapy consolidation appears effective and safe for patients with stage III NSCLC who have failed neoadjuvant chemoimmunotherapy.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.