ArticleTranslational cancer research2026
Experimental study of ultrasound combined with microbubbles augmenting the sonodynamic therapy of 5-aminolevulinic acid in glioma cells.
Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Sonodynamic therapy (SDT) is a promising non-invasive modality for cancer treatment. This Methods: Results: Flow cytometry and CLSM results indicated that the level of protoporphyrin IX (PpIX) in cells was significantly enhanced after treatment with US combined with MBs and 5-ALA (US-MBs-5-ALA group). MTS analysis demonstrated that the cell viability was significantly reduced in the US-MBs-5-ALA group. Qualitative observations from TEM revealed that mitochondria in cells subjected to low-intensity US treatment alone showed swelling and vacuolization. Upon combined treatment with US and 5-ALA, cells exhibited apoptotic features such as nuclear condensation and crescent-shaped structures. Moreover, mitochondrial damage was more severe in the US-MBs-5-ALA group. Qualitative analysis by CLSM showed that the level of ROS in the US-MBs-5-ALA group was significantly increased. These results suggest a mechanistic link where US-MBs enhance 5-ALA uptake, leading to increased ROS generation under sonication, which in turn induces mitochondrial damage and promotes cytotoxicity. Conclusions: These preliminary
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