Evidence map›Paper›PMID 41969504›Full record

ArticleTranslational cancer research2026

Clinical characteristics, prognosis, and nomograms for lung invasive mucinous adenocarcinoma with distant metastasis: a population-based study.

Xiaomei Luo, Qian Chen

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Article in Translational cancer research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

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2 authors.

Xiaomei LuoDepartment of Pediatrics, Children Hematological Oncology and Birth Defects Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, China.
Qian ChenDepartment of Pediatrics, Children Hematological Oncology and Birth Defects Laboratory, The Affiliated Hospital of Southwest Medical University, Luzhou, China.ORCID https://orcid.org/0000-0001-8798-9277

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Lung invasive mucinous adenocarcinoma (LIMA) is a rare and distinct subtype of lung cancer, characterized by a relatively poor prognosis. Among LIMA patients, distant metastasis (DM) is a commonly observed and fatal feature, however, the prognostic patterns in these patients remain poorly understood. Identifying the factors influencing DM and prognosis in LIMA patients is crucial for improving individualized management and treatment strategies. This study aimed to identify key factors associated with LIMA-related DM and prognosis, and construct predictive nomograms to guide clinical practice. Methods: This retrospective cohort study utilized data from the Surveillance, Epidemiology, and End Results (SEER) database, including LIMA patients diagnosed between 2004 and 2015. Logistic regression analysis was conducted to identify independent risk factors for DM in LIMA patients, while Cox regression analysis was used to determine independent prognostic factors for LIMA patients with DM. Based on these analyses, two nomograms were developed to predict the incidence and prognosis of DM in LIMA patients. The performance of these monograms was evaluated using receiver operating characteristic (ROC) curves, decision curve analysis (DCA), calibration curves, and Kaplan-Meier (K-M) analyses. Results: A total of 4,439 LIMA patients were included in the study, of which 830 patients presented with DM at the time of diagnosis. Independent risk factors for DM in LIMA patients included primary tumor site, histological grade, T-stage, and N-stage. Prognostic factors for LIMA patients with DM were age, sex, grade, tumor size, T-stage, N-stage, receipt of surgery, and chemotherapy. The validation of the nomograms in both the training and validation cohorts demonstrated robust predictive accuracy for the incidence and prognosis of DM in LIMA patients, as evidenced by the ROC curves, calibration curves, DCA, and K-M analysis. Conclusions: Two nomograms were developed to predict the risk of DM and the prognosis of LIMA patients with DM. Both nomograms demonstrated high predictive accuracy and may serve as useful tools for personalized clinical decision-making, facilitating the management of LIMA patients with DM.

Indexed as

distant metastasis (DM)Lung invasive mucinous adenocarcinoma (LIMA)nomogrampredictorprognosis

Identifiers

PMID41969504
PMCPMC13066973

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