Evidence map›Paper›PMID 41969431›Full record

ArticleJournal of transplantation2026

Postoperative Outcomes and Risk Profiles in Dual Liver-Lung Transplantation: A Single-Center Retrospective Analysis.

Abdulmalik Saleem, Omar Ilyas, Mark Obri, Ahmad Alomari, Muhammad Saad Faisal, Haya Omeish, Ammad Chaudhary, Yara Dababneh, Uthman Shukairy, Shunji Nagai and 4 more

Abstract read
In one paragraph

Article in Journal of transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Abdulmalik SaleemDepartment of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA, henryford.com.ORCID https://orcid.org/0000-0001-8555-8721
Omar IlyasDepartment of Internal Medicine, Michigan State University College of Human Medicine, East Lansing, Michigan, USA, msu.edu.ORCID https://orcid.org/0000-0003-4554-7125
Mark ObriDepartment of Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, Michigan, USA, henryford.com.
Ahmad AlomariDepartment of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA, henryford.com.
Muhammad Saad FaisalDepartment of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA, henryford.com.ORCID https://orcid.org/0009-0004-4785-7922
Haya OmeishDepartment of Internal Medicine, Henry Ford Hospital, Detroit, Michigan, USA, henryford.com.
Ammad ChaudharyDepartment of Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, Michigan, USA, henryford.com.ORCID https://orcid.org/0000-0003-2986-3988
Yara DababnehDepartment of Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, Michigan, USA, henryford.com.
Uthman ShukairyDepartment of Internal Medicine, Cornell University School of Medicine, Ithaca, New York, USA.ORCID https://orcid.org/0009-0004-1540-5681
Shunji NagaiDepartment of Transplant Surgery, Henry Ford Hospital, Detroit, Michigan, USA, henryford.com.
Domingo Franco-PalaciosDepartment of Pulmonary Transplant, Henry Ford Hospital, Detroit, Michigan, USA, henryford.com.ORCID https://orcid.org/0000-0002-0325-6744
Deepak VenkatDepartment of Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, Michigan, USA, henryford.com.
Adarsh VarmaDepartment of Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, Michigan, USA, henryford.com.ORCID https://orcid.org/0009-0008-2817-6223
Syed-Mohammed JafriDepartment of Gastroenterology and Hepatology, Henry Ford Hospital, Detroit, Michigan, USA, henryford.com.ORCID https://orcid.org/0000-0001-8108-7408

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Dual liver-lung transplantation (DLLT) is an uncommon but definitive therapy for carefully selected patients with concurrent end-stage hepatic and pulmonary disease. The combined operative complexity and dual-organ immunosuppressive burden may predispose recipients to early morbidity and graft-threatening complications [1-4]. Objective: To characterize early and late postoperative events (including acute cellular rejection (ACR), infectious complications, malignancy, and hospital readmissions) after DLLT and to describe associated clinical patterns. Methods: We performed a retrospective cohort study of adult DLLT recipients at a single tertiary center (2013-2024). Variables included demographics, transplant indications, ischemia times, readmissions (0-3 months; 3-12 months), infections (timing/etiology/site), biopsy-proven rejection, malignancy, and survival. ACR was biopsy-confirmed in cases of unexplained transaminitis beyond 30 days posttransplant. Analyses were descriptive, consistent with STROBE recommendations for small cohorts. Results: Ten patients (mean age 53.7 years; 50% female) underwent DLLT. Liver etiologies included alcohol-related cirrhosis ( Conclusions: DLLT is associated with early readmission and a high infectious burden, particularly invasive fungal disease after steroid-treated ACR. Despite significant early morbidity, short-term survival is favorable. Multicenter studies are needed to refine candidate selection, balance rejection prophylaxis with antifungal strategies, and standardize long-term oncologic and dermatologic surveillance in DLLT.

Indexed as

acute cellular rejectionbiliary complicationsdual liver–lung transplantationfungal infectionimmunosuppressionsurvival

Identifiers

PMID41969431
PMCPMC13062655

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.