ArticleNAR molecular medicine2026
Functional role of Galectin-9 in nucleic acid trafficking and transcription post-electrotransfection.
Article in NAR molecular medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Mechanisms and Strategies for Enhancing DNA Nuclear Entry in Gene Delivery.Cellular and molecular bioengineering · 2026Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Galectin-9 (Gal9) is known for its cytoplasmic roles in vesicular damage responses, yet its active functional roles in gene delivery remain unclear. Here, we investigated Gal9 dynamics in electrotransfection (ET), a non-viral gene delivery method widely used for plasmid DNA (pDNA) and mRNA transfection. Confocal imaging revealed unexpected nuclear accumulation of Gal9 after pDNA ET. Gal9 colocalized with SC35, a biomarker of nuclear speckles, and immunogold TEM confirmed its enrichment within those electron-dense, subnuclear domains following pDNA ET. Functionally, Gal9 knockdown markedly reduced ET efficiency and reporter gene expression, whereas overexpression enhanced both. The timing and the extent of Gal9-pDNA association varied with delivery method and cargo type, being prominent for DNA but minimal for mRNA. Across different cell types, endogenous Gal9 expression correlated with ET efficiency. These findings revealed previously unrecognized, active functional roles of Gal9 in organizing exogenous DNA within transcriptionally active regions of the nucleus and regulating transgene expression following their non-viral delivery.
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Registered trials
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