ArticleRSC advances2026
CellTrap: an instrument-free microfluidic platform for cell-cell interactions at stochastically generated effector-to-target ratios.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
6 authors.
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Abstract
Immune-cancer cell interactions play a central role in understanding antitumor responses and evaluating immunotherapies. However, long-term, single-cell-level analysis of these interactions remains challenging. To address this, we developed CellTrap, an instrument-free, perfusion-capable microfluidic device featuring 1024 parallel traps. Each trap is equipped with a filter constriction to stably retain cells under hydrostatic flow, sustain continuous medium perfusion, and minimize trap-to-trap crosstalk. By intentionally leveraging stochastic Poisson loading, a single seeding step simultaneously generates perfectly matched internal controls alongside variable effector-to-target (E : T) ratios across the array. Device characterization using 10 µm fluorescent beads and cells validated the predictable trap occupancy governed by Poisson statistics. Initial proof-of-concept experiments using primary human PBMCs against GFP-expressing U87 (U87
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Registered trials
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