Evidence map›Paper›PMID 41969370›Full record

ArticleCerebral circulation - cognition and behavior2026

Cross-sectional investigation of choroid plexus calcification, cardiovascular risk score, and APOEε4 Status in cognitively normal cohort.

Sarah Jun, Xiuyuan Hugh Wang, Liangdong Zhou, Ilker Ozsahin, Thomas Maloney, Edward Spector, Seyed Hani Hojjati, Emily Tanzi, Qolamreza Ray Razlighi, Yi Li and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral circulation - cognition and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Sarah JunBrain Health Imaging Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Xiuyuan Hugh WangBrain Health Imaging Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Liangdong ZhouBrain Health Imaging Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Ilker OzsahinOperational Research Center in Healthcare, Near East University, Nicosia/TRNC, Mersin 10, Turkey.
Thomas MaloneyBrain Health Imaging Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Edward SpectorBrain Health Imaging Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Seyed Hani HojjatiBrain Health Imaging Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Emily TanziBrain Health Imaging Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Qolamreza Ray RazlighiBrain Health Imaging Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Yi LiBrain Health Imaging Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Gloria C ChiangBrain Health Imaging Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Mony J de LeonBrain Health Imaging Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Henry RusinekDepartment of Radiology, New York University, New York, NY, USA.
Lidia GlodzikBrain Health Imaging Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.
Tracy ButlerBrain Health Imaging Institute, Department of Radiology, Weill Cornell Medicine, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The choroid plexus (CP), known for producing cerebrospinal fluid, is increasingly implicated in the pathogenesis of Alzheimer's disease (AD). Neuroimaging studies document structural CP alterations in aging and AD. One such alteration, calcium deposition, increases with age and is typically considered benign, though the mechanism and clinical significance of CP calcification remain uncertain. Given established association between peripheral vascular calcification and cardiovascular risk, we hypothesized that the volume of calcium within CP would correlate with systemic cardiovascular health. Based on prior findings of APOEε4-specific associations between CP calcium and neurodegeneration, participants were stratified by APOEε4 status, a strong genetic risk factor for AD also implicated in cardiovascular disease. In this retrospective analysis of 105 adults (mean age 58.9 years; 39 APOEε4+), we examined whether CP calcium correlates with cardiovascular risk in cognitively normal adults. CP calcium was quantified using a previously validated MRI-CT method. Spearman correlations assessed the association of CP calcium and Framingham Cardiovascular Risk Score (FCRS), as well as individual cardiovascular risk factors. Overall, CP calcium was not associated with FCRS. Among APOEε4- subjects, CP calcium correlated positively with FCRS (

Indexed as

APOECalcificationCardiovascular riskCardiovascular risk scoresChoroid plexus

Identifiers

PMID41969370
PMCPMC13068796

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.