Evidence map›Paper›PMID 41969329›Full record

ArticleCurrent urology2026

From ChatGPT to UroGPT: A guideline-trained artificial intelligence model for male infertility.

Elie Kaplan-Marans, Yitzchak E Katlowitz, Michael West, Navid Leelani, Christopher Edwards, David Silver, Jacob Khurgin

Abstract read
In one paragraph

Article in Current urology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Elie Kaplan-MaransDivision of Urology, Maimonides Health, New York, NY, USA.
Yitzchak E KatlowitzDivision of Urology, Maimonides Health, New York, NY, USA.
Michael WestDivision of Urology, Maimonides Health, New York, NY, USA.
Navid LeelaniDivision of Urology, Maimonides Health, New York, NY, USA.
Christopher EdwardsDivision of Urology, Maimonides Health, New York, NY, USA.
David SilverDivision of Urology, Maimonides Health, New York, NY, USA.
Jacob KhurginDivision of Urology, Maimonides Health, New York, NY, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: ChatGPT is not yet sufficiently reliable for answering clinical questions relevant to direct patient care. We hypothesized that a GPT model trained exclusively on expert guidelines would provide more accurate, guideline-concordant responses. Materials and methods: With permission from the European Association of Urology, we developed UroGPT, a custom GPT model trained solely on the European Association of Urology guidelines. We posed 25 clinical questions derived from the Male Infertility Guidelines and expert opinions to both the standard ChatGPT (GPT-4o) and UroGPT. Responses were anonymized and graded by 2 blinded reviewers as "complete and accurate," "incomplete but accurate," and "incorrect or misleading." Guideline concordance was compared using the chi-square test. Results: UroGPT demonstrated significantly greater concordance with guideline-based responses than ChatGPT ( Conclusions: UroGPT markedly outperformed ChatGPT in guideline concordance. Training artificial intelligence models on expert-authored content represents a meaningful step toward developing clinically useful large language models. However, UroGPT is not yet appropriate for direct patient care and should currently be used only for research and academic purposes.

Indexed as

Artificial intelligenceChatbotChatGPTUroGPT

Identifiers

PMID41969329
PMCPMC13068478

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.