ArticleJournal of multidisciplinary healthcare2026
Effect of Prehabilitation-Based Individualized Dietary Guidance on Nutrition and Short-Term Quality of Life in Locally Advanced Gastric Cancer Patients Undergoing Surgery: A Single-Center Randomized Controlled Trial.
Article in Journal of multidisciplinary healthcare, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate the effect of individualized dietary guidance based on the prehabilitation concept on nutritional outcomes and quality of life (QoL) in patients with locally advanced gastric cancer (LAGC) undergoing surgery. Methods: This is a single-center randomized controlled trial (RCT). Patients who underwent radical gastrectomy following neoadjuvant therapy were included at the First Affiliated Hospital of Soochow University between January 2023 and October 2025 and randomly assigned to either the control group or the intervention group. Both groups received standard perioperative care. The control group received nutritional support, while the intervention group received individualized dietary guidance based on the Patient-Generated Subjective Global Assessment (PG-SGA) in combination with the prehabilitation concept. Nutritional parameters [albumin (Alb), prealbumin (PA), and hemoglobin (Hb)] and Prognostic Nutritional Index (PNI) were assessed at preoperative baseline and postoperative day 5-7 (before discharge). Quality of life (QoL) was evaluated using the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30) at baseline and 3 months post-intervention. Postoperative safety and short-term outcomes, including length of stay (LOS), complications (classified by Clavien-Dindo grade), mortality, and readmission within 3 months, were also recorded. Results: A total of 120 patients were eligible for the study between January 2023 and October 2025, of whom 72 were approached and enrolled (response rate: 60%), with 36 in each group. Compared with the control group, the intervention group showed significantly better nutritional indices after the intervention. In contrast, the control group showed significant decreases in PNI (52.64±4.98 vs 43.28±4.73), Alb (42.87±4.73 vs 36.67±6.28 g/L), PA (229.12±39.43 vs 179.32±32.72 mg/L), and Hb (134.92±21.63 vs 113.54±18.21 g/L), whereas no significant within-group changes were observed in the intervention group. EORTC QLQ-C30 scores for all functional domains (except cognitive functioning and financial difficulties) significantly increased, while scores for all symptom domains and single items (except financial difficulties) significantly decreased in both groups. Following the intervention, the intervention group demonstrated significantly higher PNI (51.21±5.27 vs 43.28±4.73, Conclusion: Prehabilitation-based individualized dietary guidance effectively improves short-term nutritional outcomes and enhances QoL in patients with LAGC undergoing surgery following neoadjuvant therapy. The intervention demonstrated a favorable safety profile, with no increase in complications, mortality, or readmissions. This single-center study provides preliminary evidence, and long-term outcomes (e.g. survival, readmission) were not evaluated.
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