Evidence map›Paper›PMID 41969048›Full record

ArticlePsychological medicine2026

Elevated C-reactive protein is associated with suicide attempts in youth with bipolar disorder.

Dharmayu Desai, Mikaela K Dimick, Kody G Kennedy, Alysha A Sultan, Megan Mio, Benjamin I Goldstein

Abstract read
In one paragraph

Article in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Dharmayu DesaiCentre for Youth Bipolar Disorder, https://ror.org/03e71c577Centre for Addiction and Mental Health, Toronto, Canada.ORCID 0009-0008-1547-8791
Mikaela K DimickCentre for Youth Bipolar Disorder, https://ror.org/03e71c577Centre for Addiction and Mental Health, Toronto, Canada.ORCID 0000-0001-8371-1585
Kody G KennedyCentre for Youth Bipolar Disorder, https://ror.org/03e71c577Centre for Addiction and Mental Health, Toronto, Canada.ORCID 0000-0002-4510-188X
Alysha A SultanCentre for Youth Bipolar Disorder, https://ror.org/03e71c577Centre for Addiction and Mental Health, Toronto, Canada.ORCID 0000-0002-2718-292X
Megan MioCentre for Youth Bipolar Disorder, https://ror.org/03e71c577Centre for Addiction and Mental Health, Toronto, Canada.
Benjamin I GoldsteinCentre for Youth Bipolar Disorder, https://ror.org/03e71c577Centre for Addiction and Mental Health, Toronto, Canada.ORCID 0000-0003-0340-349X

Funding

Brain and Behavior Research FoundationCIHR 119525CIHR 136947Heart and Stroke Foundation of CanadaSunnybrook Research InstituteTemerty Faculty of Medicine, University of Toronto
6 · The paper itself

Abstract

backgroundC-reactive protein (CRP) has been studied in relation to bipolar disorder (BD) and suicidality independently. Although suicide risk is elevated in youth with BD, little is known about the association of CRP with suicidality in this population.

methods211 youth participated, including 23 BD with lifetime suicide attempts (BD

resultsCRP levels differed across groups (

conclusionsSuicide attempts among youth with BD are associated with elevated CRP. Given accessibility of CRP testing, the present findings have potential clinical implications. Larger, longitudinal studies with repeated measures are needed to examine time-varying associations between CRP and suicide risk among youth with BD.

Indexed as

Bipolar DisorderC-Reactive ProteinSelf-Injurious BehaviorSuicide, AttemptedAdolescentCase-Control StudiesFemaleHumansMaleC-Reactive Proteinbipolar disorderC-reactive proteinsuicideyouth

Identifiers

PMID41969048
PMCPMC13079216

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.