Evidence map›Paper›PMID 41969027›Full record

ArticleDalton transactions (Cambridge, England : 2003)2026

A bis-macrocylic peptide ligand mimicking the β-sandwich active site of multicopper oxidases.

Viet Thuc Dang, Alexander Drena, Joshua Telser, Lane Wofford, Andy I Nguyen

Erratum issuedAbstract read
In one paragraph

Article in Dalton transactions (Cambridge, England : 2003), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Viet Thuc DangDepartment of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA. andyn@uic.edu.
Alexander DrenaDepartment of Chemistry, Northwestern University, Evanston, IL 60208, USA.
Joshua TelserCollege of Science, Health, and Pharmacy, Roosevelt University, Chicago, IL 60605, USA.ORCID http://orcid.org/0000-0003-3307-2556
Lane WoffordDepartment of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA. andyn@uic.edu.
Andy I NguyenDepartment of Chemistry, University of Illinois Chicago, Chicago, IL 60607, USA. andyn@uic.edu.ORCID http://orcid.org/0000-0003-4137-6453

Funding

In crystallo biomimetic oxygenase chemistry within peptidic frameworksR35GM154793 · NIGMS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Andy I Nguyen · 2024 to 2026
$1.1M
NIGMS NIH HHS R35 GM154793
6 · The paper itself

Abstract

The active site of multicopper oxidases contains three Cu ions coordinated to a β-sandwich motif. Here, we designed a small peptide ligand that closely mimics the β-sandwich. We verified the sandwich architecture by X-ray crystallography, showing its high resemblance to the active site and ability to coordinate two Cu(II) ions.

Indexed as

Biomimetic MaterialsCopperOxidoreductasesPeptidesCatalytic DomainCrystallography, X-RayLigandsModels, MolecularCopperLigandsOxidoreductasesPeptides

Identifiers

PMID41969027
PMCPMC13182529

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.