Evidence map›Paper›PMID 41968832›Full record

ReviewThe journals of gerontology. Series A, Biological sciences and medical sciences2026

Frailty and genetics: linking molecular aging to clinical vulnerability.

Jhuliana Castillo, Natalia García, Fernando Gómez

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in The journals of gerontology. Series A, Biological sciences and medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jhuliana CastilloResearch Group on Geriatrics and Gerontology, Faculty of Health Sciences, Universidad de Caldas, Manizales, Colombia.ORCID 0000-0003-4773-037X
Natalia GarcíaHead of the Research Office, Vicerrectoría de investigaciones, Universidad de Caldas, Manizales, Colombia.
Fernando GómezResearch Group on Geriatrics and Gerontology, Faculty of Health Sciences, Universidad de Caldas, Manizales, Colombia.ORCID 0000-0003-4360-8174

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aging is a multifactorial process involving cumulative cellular and molecular damage, directly affecting physiological reserve and homeostasis. In this context, frailty emerges as a complex, dynamic, and potentially reversible geriatric syndrome, associated with inflammatory dysregulation, immunosenescence, and genetic alterations. This narrative review presents the most recent findings linking frailty to genetic factors, including genome-wide association studies and specific polymorphisms related to inflammation. The genetic relationship between frailty and various chronic comorbidities is also explored. This genetic perspective provides a promising framework for a better understanding of the etiopathogenesis of frailty and highlights new opportunities for individualized interventions.

Indexed as

AgingFrailtyAgedFrail ElderlyGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansInflammationPolymorphism, Single NucleotideAgingInflammagingInflammatory cytokinesMolecular pathwaysSingle-nucleotide polymorphisms

Identifiers

PMID41968832
PMCPMC13120882

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.