ArticleJournal of periodontal & implant science2026
Synergistic effects of lipopolysaccharide and titanium ions on monocytic myeloid-derived suppressor cell expansion in gingival tissue: implications for peri-implant bone health.
Article in Journal of periodontal & implant science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Research advances in early diagnosis and treatment strategies for peri-implantitis: from microecology to regenerative therapy.Frontiers in cellular and infection microbiology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
purposeTitanium particles and ions detected in peri-implant tissues have been implicated in crestal bone loss around dental implants. However, their precise effects on adjacent peri-implant structures remain insufficiently understood. This study investigates the impact of foreign body reactions induced by titanium ions on peri-implant bone levels, with a specific focus on monocytic myeloid-derived suppressor cells (M-MDSCs), which have been reported to possess osteoclast precursor potential.
methodsBone marrow, spleen, and gingival cells were exposed to titanium ions and lipopolysaccharide (LPS) to evaluate M-MDSC differentiation using flow cytometry. In addition, an
resultsTitanium ions enhanced the differentiation of M-MDSCs and macrophages from bone marrow-derived precursors.
conclusionsTitanium ions and inflammatory stimuli synergistically promote not only the expansion of M-MDSCs but also their osteoclastogenic priming. These findings suggest that primed M-MDSCs may function as key cellular mediators in the pathogenesis of peri-implantitis. Furthermore, they highlight M-MDSCs as a potential therapeutic target for improving implant longevity and underscore the importance of controlling peri-implant inflammation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.