ArticleJournal of periodontal & implant science2026
Correlations between early ultrasound markers and the outcomes of staged lateral guided bone regeneration.
Article in Journal of periodontal & implant science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05013580 (The "Open Wound Bone Augmentation Concept" with Amnion-Chorion Membrane), which is not on this map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The "Open Wound Bone Augmentation Concept" with Amnion-Chorion Membrane: a Randomized Controlled Trial
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Authors and funding
7 authors.
Funding
Abstract
purposeGuided bone regeneration (GBR) is a widely used strategy for augmenting lost jawbone. The extent of bone gain varies among patients and typically remains unknown until after a healing period of 4-6 months. This study aims to demonstrate the use of novel ultrasonography techniques to provide predictive values for bone gain.
methodsThis study included 16 subjects with 20 edentulous ridges undergoing GBR for lateral bone deficiencies of 1-3 mm in the posterior mandible. Ultrasound (US) images were captured at the surgical site 10 days postoperatively. Four US-derived parameters were assessed: tissue perfusion, wound approximation, tissue swelling, and bone integrity. Each parameter was categorized as either "yes" or "no." These parameters were then correlated with bone gain, measured from pre-intervention and 5-month post-intervention cone-beam computed tomography images.
resultsThis study assessed 20 sites (mean patient age, 58 years) with resorbable membranes and mixed mineralized/demineralized cortical allografts. The mean bone gain was 1.5 mm (standard deviation, 2.54 mm; range, -4.86 to 7.31 mm). Significantly greater bone gain was observed in cases with favorable wound approximation and biomaterial stability. The multivariate linear regression analysis revealed a significant association between biomaterial stability and bone gain, with an average gain of 4.56 mm (95% confidence interval, 2.28 to 6.84;
conclusionsThese newly developed US parameters could potentially predict bone gain as early as 10 days following GBR. While proper wound approximation is crucial, the stability of biomaterials may ultimately determine the outcome of GBR.
trial registrationClinicalTrials.gov Identifier: NCT05013580.
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