ArticleJournal of periodontal & implant science2026
Relationship between the miR-146a rs57095329 polymorphism and the risk of peri-implantitis.
Article in Journal of periodontal & implant science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeEmerging evidence highlights genetic susceptibility as a pivotal factor in the pathogenesis of peri-implantitis. The present study aimed to examine the potential association between the microRNA (miR)-146a rs57095329 polymorphism and susceptibility to peri-implantitis.
methodsA total of 230 patients with implant-supported dentures free of peri-implantitis and 230 patients diagnosed with peri-implantitis were recruited. Genotyping was performed using the restriction fragment length polymorphism polymerase chain reaction (PCR) technique, and miR-146a expression was analyzed using real-time qualitative PCR. The Hardy-Weinberg equilibrium test was used to confirm whether the genotype distribution matched expected values. Logistic regression analysis was then conducted to identify potential independent risk indicators.
resultsmiR-146a expression was significantly higher in the peri-implantitis group, with expression levels following the order: AA genotype > GA genotype > GG genotype. The AA genotype (odds ratio [OR], 2.753; 95% confidence interval [CI], 1.510-5.019;
conclusionsThe miR-146a rs57095329 polymorphism was significantly associated with susceptibility to peri-implantitis.
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