ArticleEndocrine, metabolic & immune disorders drug targets2026
Relationship between Insulin Resistance and Circulating Stem and Progenitor Cells in Newlydiagnosed Youth-onset Type 2 Diabetes.
Article in Endocrine, metabolic & immune disorders drug targets, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
introductionTo investigate the relationship between insulin resistance (IR) and circulating stem cells and endothelial progenitor cells (EPCs) in youth-onset type 2 diabetes mellitus (T2DM).
methodsA total of 392 newly diagnosed T2DM patients aged 12-25 years were enrolled. General data, medical history, and anthropometric indices were collected. Blood glucose, lipid profiles, and glycated hemoglobin (HbA1c) were measured. IR was assessed using the homeostatic model assessment of insulin resistance (HOMA-IR). Circulating stem cells (CD34
resultsWhen stratified by HOMA-IR tertiles, significant differences were observed across groups in CD34 DISCUSSION: Our results indicate that insulin resistance plays a crucial, reversible role in the development of early vascular damage among adolescents with type 2 diabetes. This highlights the importance of implementing early interventions aimed at improving insulin sensitivity in this vulnerable population.
conclusionHOMA-IR was independently associated with reduced levels of circulating stem cells and EPCs in youth-onset type 2 diabetes, indicating its role as an independent risk factor for vascular endothelial dysfunction in this population.
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