ArticleOrganic letters2026
Development and Mechanistic Studies of Oxidative Prins-Semipinacol Cyclization Reactions.
Article in Organic letters, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
4 authors.
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Abstract
This work shows that allylic alcohols or silyl ethers promote hydride abstraction leading to direct carbon-carbon bond formation or carbon-oxygen bond formation followed by rearrangement, providing the stereoselective construction of spirocyclic ethers through a Prins-semipinacol pathway. A kinetic isotope effect study showed that hydride abstraction is the rate-determining step, consistent with the presence of a distal nucleophilic group lowering the transition state free energy of the oxidation step.
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