Evidence map›Paper›PMID 41968523›Full record

ArticleJournal of clinical laboratory analysis2026

Genomic Insights Into Carbapenem-Resistant Klebsiella pneumoniae in Pediatric Bloodstream Infections in Zhejiang, China (2019-2024).

Mingming Zhou, Xiucai Zhang, Zhenjie Chen, Chao Fang, Shixing Liu, Jintao Xia, Yining Zhao, Chenmei Zhang, Hongqiang Shen

Abstract read
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In one paragraph

Article in Journal of clinical laboratory analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Mingming ZhouDepartment of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China.
Xiucai ZhangDepartment of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China.
Zhenjie ChenDepartment of Pediatric Intensive Care Unit, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China.
Chao FangDepartment of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China.ORCID https://orcid.org/0000-0002-3903-9303
Shixing LiuDepartment of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China.
Jintao XiaDepartment of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China.
Yining ZhaoDepartment of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China.
Chenmei ZhangDepartment of Pediatric Intensive Care Unit, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China.
Hongqiang ShenDepartment of Clinical Laboratory, Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Children and Adolescents' Health and Diseases, Hangzhou, China.

Funding

National Key Research and Development Program of China 2021YFC2701800National Key Research and Development Program of China 2021YFC2701801the Key Program of the Independent Design Project of the National Clinical Research Center for Child Health I23J0006Zhejiang Provincial Natural Science Foundation of China LTGC23H200006
6 · The paper itself

Abstract

objectivesBloodstream infections (BSIs) caused by Klebsiella pneumoniae are associated with a significant risk of mortality. While the majority of existing research has concentrated on adult populations, there is a paucity of studies addressing pediatric cases. This study aims to elucidate the mechanisms underlying carbapenem resistance in K. pneumoniae strains responsible for bloodstream infections in children.

methodsA retrospective study was conducted at Children's Hospital, Zhejiang University School of Medicine, focusing on patients diagnosed with bloodstream infections due to carbapenem-resistant K. pneumoniae (CRKP). Antimicrobial susceptibility testing and whole-genome sequencing were subsequently performed.

resultsIn this study, all the CRKP-BSI strains were detected during the COVID-19 pandemic. The predominant mechanism of carbapenem resistance among the 10 CRKP-BSI strains was the production of class B metallo-beta-lactamases, with bla

conclusionsThis study determined that the production of class B metalloenzymes is the primary mechanism of carbapenem resistance in pediatric bloodstream infections caused by CRKP. Importantly, the ST25-KL2 lineage emerged as the dominant clone, highlighting its potential for nosocomial transmission.

Indexed as

BacteremiaCarbapenemsKlebsiella InfectionsKlebsiella pneumoniaeAnti-Bacterial AgentsChildChild, PreschoolChinaFemaleHumansInfantInfant, NewbornMaleMicrobial Sensitivity TestsRetrospective StudiesWhole Genome SequencingAnti-Bacterial AgentsCarbapenemsbloodstream infectioncarbapenem‐resistancechildrenCOVID‐19Klebsiella pneumoniaepediatric

Identifiers

PMID41968523
PMCPMC13240236

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.