ArticleChemical research in toxicology2026
Neutralization Kinetics and Transport Define the Dermal Decontamination Window for Warfare and Industrial Toxicants.
Article in Chemical research in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Chemical warfare agents that are moderately to highly volatile can readily permeate the skin, posing an acute systemic toxicity risk. Effective decontamination depends on how intervention timing and chemical reactivity jointly shape dermal absorption, evaporation, and neutralization. While earlier finite-dose models characterized dermal uptake, they lacked decontaminant reactivity and failed to quantify how neutralization competes with diffusion and surface clearance. This work presents a unified, dimensionless framework integrating diffusion, evaporation, and reactive neutralization. The system behavior is governed by two dimensionless groups: a surface-loss number (
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