Evidence map›Paper›PMID 41968436›Full record

ArticleInflammatory bowel diseases2026

Effect of polydeoxyribonucleotide as a potential therapeutic agent to enhance the healing of Crohn's perianal fistula.

Hyeon Kyeong Kim, Yong Sik Yoon, Jong Lyul Lee, Eun Jung Park, Min Hyun Kim, Young Il Kim, Chan Wook Kim, In Ja Park, Seok-Byung Lim, Chang Sik Yu

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Article in Inflammatory bowel diseases, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Hyeon Kyeong KimDepartment of Surgery, College of Medicine, St. Vincent's Hospital, The Catholic University of Korea , Address 93, Jungbu-daero, Paldal-gu, Suwon-si, Gyeonggi-do, South Korea.ORCID 0000-0002-8161-0606
Yong Sik YoonDivision of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center , Address 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea.ORCID 0000-0002-3196-8423
Jong Lyul LeeDivision of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center , Address 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea.ORCID 0000-0002-5878-8000
Eun Jung ParkDivision of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center , Address 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea.ORCID 0000-0002-4559-2690
Min Hyun KimDivision of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center , Address 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea.ORCID 0000-0002-9414-7817
Young Il KimDivision of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center , Address 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea.ORCID 0000-0002-0212-9196
Chan Wook KimDivision of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center , Address 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea.ORCID 0000-0002-2382-0939
In Ja ParkDivision of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center , Address 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea.ORCID 0000-0001-5355-3969
Seok-Byung LimDivision of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center , Address 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea.ORCID 0000-0001-8824-4808
Chang Sik YuDivision of Colon and Rectal Surgery, Department of Surgery, University of Ulsan College of Medicine, Asan Medical Center , Address 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, South Korea.ORCID 0000-0001-9401-9981

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe treatment of Crohn's perianal fistula remains challenging owing to its recurrent nature and resistance to complete healing. This study aimed to assess the postoperative outcomes, including fistula closure rates, following Crohn's perianal fistula surgery, with and without polydeoxyribonucleotide administration.

methodsA retrospective review was conducted on patients who underwent fistula closure operations for Crohn's perianal fistula at a single tertiary center in Seoul, Korea, between January 2018 and June 2024. Patients were divided into two groups based on the use of local polydeoxyribonucleotide (PDRN) injections during fistula closure operations, and clinical variables and postoperative outcomes were compared between the groups.

resultsAmong the 47 patients, 21 (44.7%) were assigned to the PDRN group and 26 (55.3%) were assigned to non-PDRN group. Baseline characteristics between the two groups showed no significant difference. During the mean follow-up of 30.4 months, patients in the PDRN group demonstrated a significantly higher complete fistula closure rate (70.0% vs 26.9% at 6 months, and 83.3% vs 46.2% at 12 months; P = .005), and a shorter time from surgery to complete closure (3.3 ± 2.6 months vs 5.9 ± 3.8 months; P = .044), compared with the non-PDRN group. Multivariate analysis revealed PDRN as an independent factor significantly associated with Crohn's perianal fistula closure (HR 2.336; 95% CI, 1.092-4.997, P = .029).

conclusionsPDRN is a potential therapeutic agent that presents a viable option for Crohn's perianal fistula surgery, improving complete fistula closure rate through a safe, cost-effective, and relatively simple procedure.

Indexed as

Crohn DiseasePolydeoxyribonucleotidesRectal FistulaWound HealingAdultColorectal Surgical ProceduresFemaleFollow-Up StudiesHumansMaleMiddle AgedRetrospective StudiesTreatment OutcomePolydeoxyribonucleotidesCrohn’s diseasefistula/surgeryperianal fistulapolydeoxyribonucleotidewound healing

Identifiers

PMID41968436
PMCPMC13414546

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.