ArticleThe ISME journal2026
High-pathogenicity island enhances NDM-5 activity and drives global spread of Escherichia coli ST410.
Article in The ISME journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- Identification and Genomic Analysis of the First Salmonella typhimurium Monophasic Variant 1,4,[5],12:i:- Isolate Harbouring a Chromosomally Integrated blaMicrobial biotechnology · 2026Article
- Adaptive microevolution in CC17Frontiers in cellular and infection microbiology · 2026Article
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Authors and funding
13 authors.
Funding
Abstract
The international high-risk clone Escherichia coli ST410 poses a serious threat to clinical therapy and public health. By analyzing 3434 ST410 genomes, we observed a broad ecological and geographic distribution along with frequent acquisition of the carbapenem resistance gene blaNDM-5 and a yersiniabactin-encoding high-pathogenicity island (HPI). We found that blaNDM-5 and HPI co-occurred in the most successful subclades. Functional assays comparing the wild-type strain with its isogenic mutant demonstrated that HPI augments bacterial iron uptake, promotes growth under iron-limited conditions, and increases pathogenicity in a mouse infection model. HPI also increases intracellular zinc levels and boosts NDM-5 β-lactamase activity, thereby improving bacterial survival under imipenem exposure in vitro and in mice. These findings suggest that the successful dissemination of ST410 is propelled by a synergy between HPI-mediated metal acquisition and blaNDM-5, linking enhanced virulence with elevated antibiotic resistance. This study provides mechanistic insight into resistance-virulence co-evolution in an emerging bacterial lineage and illustrates how ecological selection imposed by metal limitation and antibiotic exposure can jointly shape the success of high-risk clones across diverse ecosystems.
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