ArticleAIDS research and therapy2026
Poor adherence to second-line antiretroviral therapy and its contributing factors among people living with HIV in Addis Ababa, Ethiopia.
Article in AIDS research and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
backgroundPoor adherence to second-line Antiretroviral Therapy (ART) remains a major risk factor for virological failure among people living with HIV (PLHIV), posing a significant public health challenge. In Ethiopia, limited data exists on this issue, prompting a study to assess adherence levels and contributing factors among adults in Addis Ababa, Ethiopia.
methodsA concurrent design, both quantitative and qualitative data were collected and analyzed using SPSS v28 and Atlas.ti v24, respectively.
resultsAmong 369 participants, 16.5% exhibited poor adherence, with varied progress over time. Following up, 89 (24%) of clients had high viral loads, and 34 (38%) of them achieved suppression after undergoing Enhanced Adherence Counseling (EAC). Key factors influencing poor adherence included the presence of opportunistic infections; clients with such conditions were over five times more likely to have poor adherence (5.186 [1.963–13.698], p = 0.001). Additionally, nondisclosure of HIV status was significantly associated with poor adherence (0.507 [95% CI: 0.265–0.971], p = 0.041). In contrast, literacy emerged as a protective factor; individuals with secondary education were 2.5 times more likely to maintain optimal adherence [95% CI: 1.061–5.925], p = 0.036). Supportive evidence was also generated from the qualitative data.
conclusionWhile many participants demonstrated good adherence, variability persisted. EAC proved effective in improving viral suppression. The study underscores the importance of targeted interventions that address opportunistic infections, promote HIV status disclosure, and enhance health literacy to improve treatment outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.