ReviewTrends in neurosciences2026
Serotonergic and glutamatergic mechanisms converge in ketamine's rapid responses.
Review in Trends in neurosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Ketamine's rapid antidepressant actions are commonly attributed to glutamatergic mechanisms. In a recent study, Luo and colleagues have shown that ketamine inhibits the serotonin transporter and that prefrontal serotonergic signaling synergizes with NMDA receptor blockade to recruit vasoactive intestinal peptide interneurons in mice, driving fast behavioral responses. These findings suggest convergent serotonergic and glutamatergic pathways underlying ketamine's antidepressant effects.
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