Evidence map›Paper›PMID 41967481›Full record

ArticleThe ISME journal2026

Cross-niche metabolite-microbiome interactions orchestrate systemic soybean resistance to Fusarium root rot.

Qi Liu, Lang Cheng, Enxi Zhang, Li Ling, Weiyi Tan, Suwen Liang, Canwei Shu, Qibin Ma, Shuai Zhao, Jian Wei and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The ISME journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Qi LiuGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory for the Development Biology and Environmental Adaptation of Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Agriculture, South China Agricultural University, No.483 Wushan Road, Guangzhou, Guangdong 510642, China.
Lang ChengGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory for the Development Biology and Environmental Adaptation of Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Agriculture, South China Agricultural University, No.483 Wushan Road, Guangzhou, Guangdong 510642, China.
Enxi ZhangGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory for the Development Biology and Environmental Adaptation of Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Agriculture, South China Agricultural University, No.483 Wushan Road, Guangzhou, Guangdong 510642, China.
Li LingGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory for the Development Biology and Environmental Adaptation of Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Agriculture, South China Agricultural University, No.483 Wushan Road, Guangzhou, Guangdong 510642, China.
Weiyi TanGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory for the Development Biology and Environmental Adaptation of Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Agriculture, South China Agricultural University, No.483 Wushan Road, Guangzhou, Guangdong 510642, China.
Suwen LiangGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory for the Development Biology and Environmental Adaptation of Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Agriculture, South China Agricultural University, No.483 Wushan Road, Guangzhou, Guangdong 510642, China.
Canwei ShuGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory for the Development Biology and Environmental Adaptation of Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Agriculture, South China Agricultural University, No.483 Wushan Road, Guangzhou, Guangdong 510642, China.
Qibin MaGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory for the Development Biology and Environmental Adaptation of Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Agriculture, South China Agricultural University, No.483 Wushan Road, Guangzhou, Guangdong 510642, China.
Shuai ZhaoState Key Laboratory of Desert and Oasis Ecology, Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi, Xinjiang 830011, China.
Jian WeiNorthern Key Laboratory of Saline-tolerant Soybean Breeding, Ministry of Agriculture and Rural Areas, Jilin Agricultural University, Changchun, Jilin 130118, China.
Yingxiang WangGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory for the Development Biology and Environmental Adaptation of Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Agriculture, South China Agricultural University, No.483 Wushan Road, Guangzhou, Guangdong 510642, China.
Hai NianGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory for the Development Biology and Environmental Adaptation of Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Agriculture, South China Agricultural University, No.483 Wushan Road, Guangzhou, Guangdong 510642, China.
Yanbo ChengGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory for the Development Biology and Environmental Adaptation of Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Agriculture, South China Agricultural University, No.483 Wushan Road, Guangzhou, Guangdong 510642, China.
Tengxiang LianGuangdong Basic Research Center of Excellence for Precise Breeding of Future Crops, Guangdong Laboratory for Lingnan Modern Agriculture, Guangdong Provincial Key Laboratory for the Development Biology and Environmental Adaptation of Agricultural Organisms, South China Institute for Soybean Innovation Research, College of Agriculture, South China Agricultural University, No.483 Wushan Road, Guangzhou, Guangdong 510642, China.ORCID 0000-0003-1131-2491

Funding

Double First-class Discipline Promotion Project 2021B10564001Guangdong Provincial Construction Project For Modern Agriculture Industry Technology System Innovation Teams 2024CXTD06National Natural Science Foundation of China 32470090Project from Guangdong Basic Research Center of Excellence for Precise Breeding of Future Crops FCBRCE-202506Science and Technology Plan Project of Guangzhou 2024A04J5487Science and Technology Plan Project of Shanwei 2024E005
6 · The paper itself

Abstract

Fusarium root rot, predominantly caused by Fusarium falciforme, poses a significant threat to soybean productivity globally. Microbiome-based strategies offer sustainable alternatives, but the mechanisms underlying multi-niche interactions remain elusive. Here, we found that a tolerant soybean cultivar (GXD2) coordinates spatially resolved metabolite signals to recruit beneficial microbes across the rhizosphere, root endosphere, and leaf endosphere. Specifically, formononetin and maltol selectively enrich Bacillus and Massilia in the rhizosphere; arctigenin and isovanillic acid recruit Bacillus and Streptomyces to the root endosphere; and flavonoids such as diosmetin attract Penicillium and Aspergillus to the leaf endosphere. Leveraging these interactions, we constructed different types of synthetic communities (SynComs) via top-down (host-selected taxa) and bottom-up (antagonist-based) strategies. Both SynComs suppressed root rot in susceptible cultivars, with foliar application of top-down SynComs significantly enhancing shoot growth. Transcriptomics revealed distinct modes of action: that top-down SynComs activated mitogen-activated protein kinase (MAPK)-linked terpenoid and flavonoid pathways, whereas bottom-up SynComs primarily modulated host carbon-nitrogen allocation, effectively limiting pathogen resources. Our findings unveil a "metabolite-mediated, multi-niche collaborative defense" model, presenting a robust framework for microbiome-based disease management and paving the way toward sustainable crop protection strategies.

Indexed as

FusariumGlycine maxMicrobiotaPlant DiseasesPlant RootsPlant LeavesPlant Systemic Acquired ResistanceRhizospheremetabolic remodulatingphyllosphere-mediated protectionroot rotSoybeanSynComs strategies

Identifiers

PMID41967481
PMCPMC13140568

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.