ArticleClinics (Sao Paulo, Brazil)2026
Short- versus long-course antibiotic therapy in mechanically ventilated sepsis patients with pneumonia: a real-world cohort analysis.
Article in Clinics (Sao Paulo, Brazil), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
objectiveTo compare outcomes of short-course versus longer-course antibiotic regimens in mechanically ventilated adult patients with sepsis due to pneumonia.
methodsThe authors performed a retrospective cohort study using the MIMIC-IV database (2008-2022), identifying 2590 adults meeting Sepsis-3 criteria with a primary diagnosis of pneumonia requiring invasive mechanical ventilation. Patients were stratified by antibiotic duration (short: 2‒7 days; long: 8‒14 days). Demographics, comorbidities, severity (SOFA score, PaO
resultsThe study found that overall 90-day mortality did not differ significantly (short-course ∼41.3% vs. long-course ∼41.2%; p = 0.98). Subgroup analyses indicated that in patients > 65-years, those with severe hypoxemia (low PaO
conclusionsIn this observational cohort, shorter antibiotic courses were not associated with increased 90‑day mortality after adjustment. Given potential confounding and limited recurrence data, subgroup signals are hypothesis‑generating and require confirmation in randomized trials.
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