Evidence map›Paper›PMID 41967179›Full record

ArticleNeurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics2026

RNA-binding protein MBNL2 mitigates neuropathic pain after chemotherapy through destabilizing CCR2 expression in primary sensory neurons.

Keshi Yan, Ruining Ma, Bing Wang, Xiaozhou Feng, Xinju Li, Xianglei Meng, Huijie Shang, Benjamin M Kidd, Maurice S Swanson, Huijuan Hu and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

11 authors.

Keshi YanDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.
Ruining MaDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.
Bing WangDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.
Xiaozhou FengDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.
Xinju LiDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.
Xianglei MengDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.
Huijie ShangDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.
Benjamin M KiddDepartment of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Maurice S SwansonDepartment of Molecular Genetics and Microbiology, Center for NeuroGenetics and the Genetics Institute, University of Florida College of Medicine, Gainesville, FL 32610, USA.
Huijuan HuDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA; Department of Physiology, Pharmacology & Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA.
Yuan-Xiang TaoDepartment of Anesthesiology, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA; Department of Physiology, Pharmacology & Neuroscience, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA; Department of Cell Biology & Molecular Medicine, New Jersey Medical School, Rutgers, The State University of New Jersey, Newark, NJ 07103, USA. Electronic address: yuanxiang.tao@njms.rutgers.edu.

Funding

Role of dorsal root ganglion FTO, a RNA demethylase, in neuropathic painR01NS111553 · NINDS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI TAO, YUAN-XIANG · 2019 to 2023
$2.5M
Identification of a Novel DRG-Specific Long Noncoding RNA and its Role in Neuropathic PainR01NS117484 · NINDS · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI HU, HUIJUAN, TAO, YUAN-XIANG · 2021 to 2025
$2.4M
Role of a diabetes-specific circular RNA in diabetic neuropathic painR01DK142785 · NIDDK · RUTGERS BIOMEDICAL AND HEALTH SCIENCES · PI Steve Davidson, Yuan-Xiang Tao · 2026 to 2026
$802k
NIDDK NIH HHS R01 DK142785NINDS NIH HHS R01 NS111553NINDS NIH HHS R01 NS117484
6 · The paper itself

Abstract

Chemotherapy drug-induced changes of gene expression in the dorsal root ganglion (DRG) are critical for the genesis of chemotherapy-induced neuropathic pain (CINP). However, the mechanisms driving these changes remain elusive. Here, we report the downregulation of muscleblind-like protein 2 (MBNL2), an RNA-binding protein, in the DRG neurons after intraperitoneal injection of paclitaxel. Rescuing this downregulation blocks an increase of the C-C chemokine receptor type 2 (CCR2) in the DRG and mitigates paclitaxel-induced mechanical allodynia, heat and cold hyperalgesia and ongoing pain. Conversely, DRG downregulation of MBNL2 increases the expression of CCR2 in the DRG neurons and leads to CINP-like symptoms in naïve mice. Mechanistically, paclitaxel-induced downregulation of MBNL2 reduces its binding to the 3'-untranslated region of Ccr2 mRNA, thereby enhancing the stability of Ccr2 mRNA in the DRG. Given that MBNL2 and CCR2 are co-expressed in DRG neurons, these findings suggest that MBNL2 alleviates CINP, likely by destabilizing CCR2 expression in the DRG, and may represent a promising therapeutic strategy for this condition.

Indexed as

NeuralgiaPaclitaxelReceptors, CCR2RNA-Binding ProteinsSensory Receptor CellsAnimalsAntineoplastic Agents, PhytogenicGanglia, SpinalMaleMiceMice, Inbred C57BLAntineoplastic Agents, PhytogenicCcr2 protein, mousePaclitaxelReceptors, CCR2RNA-Binding ProteinsAnd chemotherapy-induced neuropathic painC–C chemokine receptor type 2Dorsal root ganglionMuscleblind-like protein 2Paclitaxel

Identifiers

PMID41967179
PMCPMC13092599

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.